Journal Article

FZJ-2016-02436

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Estimating Fiber Orientation Distribution Functions in 3D-Polarized Light Imaging

Axer, M. (Corresponding author)FZJ* ; Strohmer, S.FZJ* ; Gräßel, D.FZJ* ; Bücker, O.FZJ* ; Dohmen, M. ; Reckfort, J.FZJ* ; Zilles, K.FZJ* ; Amunts, K.FZJ*

2016
Frontiers Research Foundation Lausanne

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Please use a persistent id in citations: http://hdl.handle.net/2128/10431  doi:10.3389/fnana.2016.00040

Abstract: Research of the human brain connectome requires multiscale approaches derived from independent imaging methods ideally applied to the same object. Hence, comprehensible strategies for data integration across modalities and across scales are essential. We have successfully established a concept to bridge the spatial scales from microscopic fiber orientation measurements based on 3D-Polarized Light Imaging (3D-PLI) to meso- or macroscopic dimensions. By creating orientation distribution functions (pliODFs) from high-resolution vector data via series expansion with spherical harmonics utilizing high performance computing and supercomputing technologies, data fusion with Diffusion Magnetic Resonance Imaging has become feasible, even for a large-scale dataset such as the human brain. Validation of our approach was done effectively by means of two types of datasets that were transferred from fiber orientation maps into pliODFs: simulated 3D-PLI data showing artificial, but clearly defined fiber patterns and real 3D-PLI data derived from sections through the human brain and the brain of a hooded seal.

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)
2. Jülich Supercomputing Center (JSC)

Research Program(s):

1. 574 - Theory, modelling and simulation (POF3-574) (POF3-574)
2. 511 - Computational Science and Mathematical Methods (POF3-511) (POF3-511)
3. SMHB - Supercomputing and Modelling for the Human Brain (HGF-SMHB-2013-2017) (HGF-SMHB-2013-2017)
4. HBP - The Human Brain Project (604102) (604102)
5. NIH-R01MH092311 - Postnatal Development of Cortical Receptors and White Matter Tracts in the Vervet (NIH-R01MH092311) (NIH-R01MH092311)
6. SLNS - SimLab Neuroscience (Helmholtz-SLNS) (Helmholtz-SLNS)

Appears in the scientific report 2016

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Database coverage:
; ; ; ; BIOSIS Previews ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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