%0 Journal Article
%A Vanasschen, Christian
%A Brandt, Marie
%A Ermert, Johannes
%A Coenen, Heinrich Hubert
%T Radiolabelling with isotopic mixtures of $^{52g/55}$Mn(II) as a straight route to stable manganese complexes for bimodal PET/MR imaging
%J Dalton transactions
%V 45
%N 4
%@ 0300-9246
%C London
%I The Royal Society of Chemistry
%M FZJ-2016-04017
%P 1315–1321
%D 2016
%X Radiolabelling using isotopic mixtures of 52g/55Mn(ii) offers fast and easy access to new small molecule PET/MR tracers, composed of chemically identical reporting units. trans-1,2-Diaminocyclohexane-N,N,N[prime or minute],N[prime or minute]-tetraacetic acid (CDTA) was radiolabelled with carrier-added 52gMn(ii) in >99% radiochemical yield, producing the first manganese-based bimodal PET/MR probe. The Mn-CDTA chelate was shown to be very stable to air oxidation and sufficiently inert to decomplexation in blood serum. These data sparked our interest in functionalized CDTA ligands for the design of optimized PET/MR tracers.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000369088000004
%$ pmid:26685974
%R 10.1039/C5DT04270D
%U https://juser.fz-juelich.de/record/811598