Journal Article

FZJ-2016-04017

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Radiolabelling with isotopic mixtures of $^{52g/55}$Mn(II) as a straight route to stable manganese complexes for bimodal PET/MR imaging

Vanasschen, C. (Corresponding author)FZJ* ; Brandt, M.FZJ* ; Ermert, J.FZJ* ; Coenen, H. H.FZJ*

2016
The Royal Society of Chemistry London

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Please use a persistent id in citations: doi:10.1039/C5DT04270D

Abstract: Radiolabelling using isotopic mixtures of 52g/55Mn(ii) offers fast and easy access to new small molecule PET/MR tracers, composed of chemically identical reporting units. trans-1,2-Diaminocyclohexane-N,N,N[prime or minute],N[prime or minute]-tetraacetic acid (CDTA) was radiolabelled with carrier-added 52gMn(ii) in >99% radiochemical yield, producing the first manganese-based bimodal PET/MR probe. The Mn-CDTA chelate was shown to be very stable to air oxidation and sufficiently inert to decomplexation in blood serum. These data sparked our interest in functionalized CDTA ligands for the design of optimized PET/MR tracers.

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Contributing Institute(s):

1. Nuklearchemie (INM-5)

Research Program(s):

1. 573 - Neuroimaging (POF3-573) (POF3-573)

Appears in the scientific report 2016

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Database coverage:
; Allianz-Lizenz / DFG ; Current Contents - Physical, Chemical and Earth Sciences ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; No Authors Fulltext ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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