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000811598 1001_ $$0P:(DE-Juel1)157902$$aVanasschen, Christian$$b0$$eCorresponding author
000811598 245__ $$aRadiolabelling with isotopic mixtures of $^{52g/55}$Mn(II) as a straight route to stable manganese complexes for bimodal PET/MR imaging
000811598 260__ $$aLondon$$bThe Royal Society of Chemistry$$c2016
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000811598 520__ $$aRadiolabelling using isotopic mixtures of 52g/55Mn(ii) offers fast and easy access to new small molecule PET/MR tracers, composed of chemically identical reporting units. trans-1,2-Diaminocyclohexane-N,N,N[prime or minute],N[prime or minute]-tetraacetic acid (CDTA) was radiolabelled with carrier-added 52gMn(ii) in >99% radiochemical yield, producing the first manganese-based bimodal PET/MR probe. The Mn-CDTA chelate was shown to be very stable to air oxidation and sufficiently inert to decomplexation in blood serum. These data sparked our interest in functionalized CDTA ligands for the design of optimized PET/MR tracers.
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000811598 7001_ $$0P:(DE-Juel1)131816$$aCoenen, Heinrich Hubert$$b3
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