TY  - JOUR
AU  - Vanasschen, Christian
AU  - Brandt, Marie
AU  - Ermert, Johannes
AU  - Coenen, Heinrich Hubert
TI  - Radiolabelling with isotopic mixtures of $^{52g/55}$Mn(II) as a straight route to stable manganese complexes for bimodal PET/MR imaging
JO  - Dalton transactions
VL  - 45
IS  - 4
SN  - 0300-9246
CY  - London
PB  - The Royal Society of Chemistry
M1  - FZJ-2016-04017
SP  - 1315–1321
PY  - 2016
AB  - Radiolabelling using isotopic mixtures of 52g/55Mn(ii) offers fast and easy access to new small molecule PET/MR tracers, composed of chemically identical reporting units. trans-1,2-Diaminocyclohexane-N,N,N[prime or minute],N[prime or minute]-tetraacetic acid (CDTA) was radiolabelled with carrier-added 52gMn(ii) in >99% radiochemical yield, producing the first manganese-based bimodal PET/MR probe. The Mn-CDTA chelate was shown to be very stable to air oxidation and sufficiently inert to decomplexation in blood serum. These data sparked our interest in functionalized CDTA ligands for the design of optimized PET/MR tracers.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000369088000004
C6  - pmid:26685974
DO  - DOI:10.1039/C5DT04270D
UR  - https://juser.fz-juelich.de/record/811598
ER  -