000811785 001__ 811785
000811785 005__ 20240610121200.0
000811785 0247_ $$2doi$$a10.1209/0295-5075/114/68005
000811785 0247_ $$2ISSN$$a0295-5075
000811785 0247_ $$2ISSN$$a0302-072X
000811785 0247_ $$2ISSN$$a1286-4854
000811785 0247_ $$2WOS$$aWOS:000382324500035
000811785 0247_ $$2altmetric$$aaltmetric:7351380
000811785 0247_ $$2Handle$$a2128/22906
000811785 037__ $$aFZJ-2016-04139
000811785 082__ $$a530
000811785 1001_ $$0P:(DE-HGF)0$$aMishra, Bhavya$$b0$$eCorresponding author
000811785 245__ $$aSlip of grip of a molecular motor on a crowded track: Modeling shift of reading frame of ribosome on RNA template
000811785 260__ $$aLes-Ulis$$bEDP Science65224$$c2016
000811785 264_1 $$2Crossref$$3online$$bIOP Publishing$$c2016-07-25
000811785 264_1 $$2Crossref$$3print$$bIOP Publishing$$c2016-06-01
000811785 264_1 $$2Crossref$$3print$$bIOP Publishing$$c2016-06-01
000811785 3367_ $$2DRIVER$$aarticle
000811785 3367_ $$2DataCite$$aOutput Types/Journal article
000811785 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1568815126_18993
000811785 3367_ $$2BibTeX$$aARTICLE
000811785 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000811785 3367_ $$00$$2EndNote$$aJournal Article
000811785 520__ $$aWe develop a stochastic model for the programmed frameshift of ribosomes synthesizing a protein while moving along a mRNA template. Normally the reading frame of a ribosome decodes successive triplets of nucleotides on the mRNA in a step-by-step manner. We focus on the programmed shift of the ribosomal reading frame, forward or backward, by only one nucleotide which results in a fusion protein; it occurs when a ribosome temporarily loses its grip to its mRNA track. Special "slippery" sequences of nucleotides and also downstream secondary structures of the mRNA strand are believed to play key roles in programmed frameshift. Here we explore the role of an hitherto neglected parameter in regulating −1 programmed frameshift. Specifically, we demonstrate that the frameshift frequency can be strongly regulated also by the density of the ribosomes, all of which are engaged in simultaneous translation of the same mRNA, at and around the slippery sequence. Monte Carlo simulations support the analytical predictions obtained from a mean-field analysis of the stochastic dynamics
000811785 536__ $$0G:(DE-HGF)POF3-551$$a551 - Functional Macromolecules and Complexes (POF3-551)$$cPOF3-551$$fPOF III$$x0
000811785 542__ $$2Crossref$$i2016-07-25$$uhttp://iopscience.iop.org/info/page/text-and-data-mining
000811785 542__ $$2Crossref$$i2016-07-25$$uhttp://iopscience.iop.org/page/copyright
000811785 588__ $$aDataset connected to CrossRef
000811785 7001_ $$0P:(DE-Juel1)130966$$aSchütz, Gunter M.$$b1$$ufzj
000811785 7001_ $$0P:(DE-HGF)0$$aChowdhury, Debashish$$b2
000811785 77318 $$2Crossref$$3journal-article$$a10.1209/0295-5075/114/68005$$b : IOP Publishing, 2016-06-01$$n6$$p68005$$tEPL (Europhysics Letters)$$v114$$x0295-5075$$y2016
000811785 773__ $$0PERI:(DE-600)1465366-7$$a10.1209/0295-5075/114/68005$$gVol. 114, no. 6, p. 68005 -$$n6$$p68005$$tepl$$v114$$x0295-5075$$y2016
000811785 8564_ $$uhttps://juser.fz-juelich.de/record/811785/files/epl_114_6_68005.pdf$$yRestricted
000811785 8564_ $$uhttps://juser.fz-juelich.de/record/811785/files/1605.03434.pdf$$yOpenAccess
000811785 8564_ $$uhttps://juser.fz-juelich.de/record/811785/files/epl_114_6_68005.pdf?subformat=pdfa$$xpdfa$$yRestricted
000811785 8564_ $$uhttps://juser.fz-juelich.de/record/811785/files/1605.03434.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000811785 909CO $$ooai:juser.fz-juelich.de:811785$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000811785 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)130966$$aForschungszentrum Jülich$$b1$$kFZJ
000811785 9131_ $$0G:(DE-HGF)POF3-551$$1G:(DE-HGF)POF3-550$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lBioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences$$vFunctional Macromolecules and Complexes$$x0
000811785 9141_ $$y2016
000811785 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000811785 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bEPL-EUROPHYS LETT : 2014
000811785 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000811785 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000811785 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000811785 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000811785 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000811785 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences
000811785 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000811785 915__ $$0StatID:(DE-HGF)0550$$2StatID$$aNo Authors Fulltext
000811785 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000811785 9201_ $$0I:(DE-Juel1)ICS-2-20110106$$kICS-2$$lTheorie der Weichen Materie und Biophysik$$x0
000811785 9801_ $$aFullTexts
000811785 980__ $$ajournal
000811785 980__ $$aVDB
000811785 980__ $$aUNRESTRICTED
000811785 980__ $$aI:(DE-Juel1)ICS-2-20110106
000811785 981__ $$aI:(DE-Juel1)IBI-5-20200312
000811785 981__ $$aI:(DE-Juel1)IAS-2-20090406