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@ARTICLE{Mishra:811785,
      author       = {Mishra, Bhavya and Schütz, Gunter M. and Chowdhury,
                      Debashish},
      title        = {{S}lip of grip of a molecular motor on a crowded track:
                      {M}odeling shift of reading frame of ribosome on {RNA}
                      template},
      journal      = {epl},
      volume       = {114},
      number       = {6},
      issn         = {0295-5075},
      address      = {Les-Ulis},
      publisher    = {EDP Science65224},
      reportid     = {FZJ-2016-04139},
      pages        = {68005},
      year         = {2016},
      abstract     = {We develop a stochastic model for the programmed frameshift
                      of ribosomes synthesizing a protein while moving along a
                      mRNA template. Normally the reading frame of a ribosome
                      decodes successive triplets of nucleotides on the mRNA in a
                      step-by-step manner. We focus on the programmed shift of the
                      ribosomal reading frame, forward or backward, by only one
                      nucleotide which results in a fusion protein; it occurs when
                      a ribosome temporarily loses its grip to its mRNA track.
                      Special "slippery" sequences of nucleotides and also
                      downstream secondary structures of the mRNA strand are
                      believed to play key roles in programmed frameshift. Here we
                      explore the role of an hitherto neglected parameter in
                      regulating −1 programmed frameshift. Specifically, we
                      demonstrate that the frameshift frequency can be strongly
                      regulated also by the density of the ribosomes, all of which
                      are engaged in simultaneous translation of the same mRNA, at
                      and around the slippery sequence. Monte Carlo simulations
                      support the analytical predictions obtained from a
                      mean-field analysis of the stochastic dynamics},
      cin          = {ICS-2},
      ddc          = {530},
      cid          = {I:(DE-Juel1)ICS-2-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000382324500035},
      doi          = {10.1209/0295-5075/114/68005},
      url          = {https://juser.fz-juelich.de/record/811785},
}