TY  - JOUR
AU  - Jiang, Nan
AU  - Frenzel, Daniel
AU  - Schartmann, Elena
AU  - van Groen, Thomas
AU  - Kadish, Inga
AU  - Shah, N. J.
AU  - Langen, Karl-Josef
AU  - Willbold, Dieter
AU  - Willuweit, Antje
TI  - Blood-brain barrier penetration of an Aβ-targeted, arginine-rich, d-enantiomeric peptide
JO  - Biochimica et biophysica acta / Biomembranes
VL  - 1858
IS  - 11
SN  - 0005-2736
CY  - Amsterdam
PB  - Elsevier
M1  - FZJ-2016-04556
SP  - 2717 - 2724
PY  - 2016
AB  - The application of small peptides targeting amyloid beta (Aβ) is one of many drug development strategies for the treatment of Alzheimer's disease (AD). We have previously identified several peptides consisting solely of D-enantiomeric amino acid residues obtained from mirror-image phage display selection, which bind to Aβ in different assembly states and eliminate toxic Aβ aggregates. Some of these D-peptides show both diagnostic and therapeutic potential in vitro and in vivo. Here we have analysed the similarity of the arginine-rich D-peptide D3 to the arginine-rich motif (ARM) of the human immunodeficiency virus type 1 transactivator of transcription (HIV-Tat) protein, and examined its in vivo blood-brain barrier (BBB) permeability using wild type mice and transgenic mouse models of Alzheimer's disease. We are able to demonstrate that D3 rapidly enters the brain where it can be found associated with amyloid plaques suggesting a direct penetration of BBB.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000385318800016
C6  - pmid:27423267
DO  - DOI:10.1016/j.bbamem.2016.07.002
UR  - https://juser.fz-juelich.de/record/817980
ER  -