Journal Article

FZJ-2016-04556

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Blood-brain barrier penetration of an Aβ-targeted, arginine-rich, d-enantiomeric peptide

Jiang, N.FZJ* ; Frenzel, D. ; Schartmann, E.FZJ* ; van Groen, T. ; Kadish, I. ; Shah, N. J.FZJ* ; Langen, K.-J.FZJ* ; Willbold, D. (Corresponding author)FZJ* ; Willuweit, A.FZJ*

2016
Elsevier Amsterdam

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Please use a persistent id in citations: doi:10.1016/j.bbamem.2016.07.002

Abstract: The application of small peptides targeting amyloid beta (Aβ) is one of many drug development strategies for the treatment of Alzheimer's disease (AD). We have previously identified several peptides consisting solely of D-enantiomeric amino acid residues obtained from mirror-image phage display selection, which bind to Aβ in different assembly states and eliminate toxic Aβ aggregates. Some of these D-peptides show both diagnostic and therapeutic potential in vitro and in vivo. Here we have analysed the similarity of the arginine-rich D-peptide D3 to the arginine-rich motif (ARM) of the human immunodeficiency virus type 1 transactivator of transcription (HIV-Tat) protein, and examined its in vivo blood-brain barrier (BBB) permeability using wild type mice and transgenic mouse models of Alzheimer's disease. We are able to demonstrate that D3 rapidly enters the brain where it can be found associated with amyloid plaques suggesting a direct penetration of BBB.

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Contributing Institute(s):

1. Physik der Medizinischen Bildgebung (INM-4)
2. Strukturbiochemie (ICS-6)
3. JARA-BRAIN (JARA-BRAIN)

Research Program(s):

1. 573 - Neuroimaging (POF3-573) (POF3-573)

Appears in the scientific report 2016

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Database coverage:
BIOSIS Previews ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; Nationallizenz ; No Authors Fulltext ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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