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@ARTICLE{Jiang:817980,
      author       = {Jiang, Nan and Frenzel, Daniel and Schartmann, Elena and
                      van Groen, Thomas and Kadish, Inga and Shah, N. J. and
                      Langen, Karl-Josef and Willbold, Dieter and Willuweit,
                      Antje},
      title        = {{B}lood-brain barrier penetration of an {A}β-targeted,
                      arginine-rich, d-enantiomeric peptide},
      journal      = {Biochimica et biophysica acta / Biomembranes},
      volume       = {1858},
      number       = {11},
      issn         = {0005-2736},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {FZJ-2016-04556},
      pages        = {2717 - 2724},
      year         = {2016},
      abstract     = {The application of small peptides targeting amyloid beta
                      (Aβ) is one of many drug development strategies for the
                      treatment of Alzheimer's disease (AD). We have previously
                      identified several peptides consisting solely of
                      D-enantiomeric amino acid residues obtained from
                      mirror-image phage display selection, which bind to Aβ in
                      different assembly states and eliminate toxic Aβ
                      aggregates. Some of these D-peptides show both diagnostic
                      and therapeutic potential in vitro and in vivo. Here we have
                      analysed the similarity of the arginine-rich D-peptide D3 to
                      the arginine-rich motif (ARM) of the human immunodeficiency
                      virus type 1 transactivator of transcription (HIV-Tat)
                      protein, and examined its in vivo blood-brain barrier (BBB)
                      permeability using wild type mice and transgenic mouse
                      models of Alzheimer's disease. We are able to demonstrate
                      that D3 rapidly enters the brain where it can be found
                      associated with amyloid plaques suggesting a direct
                      penetration of BBB.},
      cin          = {INM-4 / ICS-6 / JARA-BRAIN},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)ICS-6-20110106 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000385318800016},
      pubmed       = {pmid:27423267},
      doi          = {10.1016/j.bbamem.2016.07.002},
      url          = {https://juser.fz-juelich.de/record/817980},
}