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@ARTICLE{Zhu:818275,
      author       = {Zhu, Jinsheng and Bailly, Aur�lien and Zwiewka, Marta and
                      Sovero, Valpuri and di Donato, Martin and Ge, Pei and Oehri,
                      Jacqueline and Aryal, Bibek and Hao, Pengchao and Linnert,
                      Miriam and Burgardt, Noelia and Lücke, Christian and
                      Weiwad, Matthias and Michel, Max and Weiergräber, Oliver H.
                      and Pollmann, Stephan and Azzarello, Elisa and Mancuso,
                      Stefano and Ferro, Noel and Fukao, Yoichiro and Hoffmann,
                      Celine and Wedlich-Söldner, Roland and Friml, Jiri and
                      Thomas, Clement and Geisler, Markus},
      title        = {{TWISTED} {DWARF}1 mediates the action of auxin transport
                      inhibitors on actin cytoskeleton dynamics},
      journal      = {The plant cell},
      volume       = {28},
      number       = {4},
      issn         = {1040-4651},
      address      = {Rockville, Md.},
      publisher    = {Soc.},
      reportid     = {FZJ-2016-04749},
      pages        = {930-948},
      year         = {2016},
      abstract     = {Plant growth and architecture is regulated by the polar
                      distribution of the hormone auxin. Polarity and flexibility
                      of this process is provided by constant cycling of auxin
                      transporter vesicles along actin filaments, coordinated by a
                      positive auxin-actin feedback loop. Both polar auxin
                      transport and vesicle cycling are inhibited by synthetic
                      auxin transport inhibitors, such as 1-N-naphthylphthalamic
                      acid (NPA), counteracting the effect of auxin; however,
                      underlying targets and mechanisms are unclear. Using NMR, we
                      map the NPA binding surface on the Arabidopsis ABCB
                      chaperone, TWISTED DWARF1 (TWD1). We identify ACTIN7 as a
                      relevant - although likely indirect - TWD1 interactor, show
                      TWD1-dependent regulation of actin filament organization and
                      dynamics, and that TWD1 is required for NPA-mediated actin
                      cytoskeleton remodeling. The TWD1-ACTIN7 axis controls
                      plasma membrane presence of efflux transporters and as a
                      consequence act7 and twd1 share developmental and
                      physiological phenotypes indicative of defects in auxin
                      transport. These can be phenocopied by NPA treatment or by
                      chemical actin (de)stabilization. We provide evidence that
                      TWD1 determines downstream locations of auxin efflux
                      transporters by adjusting AF de-bundling and dynamizing
                      processes and mediating NPA action on the latter. This
                      function appears to be evolutionary conserved since TWD1
                      expression in budding yeast alters actin polarization and
                      cell polarity and provides NPA sensitivity.},
      cin          = {ICS-6},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000375416000012},
      pubmed       = {pmid:27053424},
      doi          = {10.1105/tpc.15.00726},
      url          = {https://juser.fz-juelich.de/record/818275},
}