Journal Article

FZJ-2016-04849

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Structure and dynamics of single-chain nano-particles in solution

Arbe, A. (Corresponding author) ; Pomposo, J. A. ; Moreno, A. J. ; LoVerso, F. ; González-Burgos, M. ; Asenjo-Sanz, I. ; Iturrospe, A. ; Radulescu, A.FZJ* ; Ivanova, O.FZJ* ; Colmenero, J.

2016
Elsevier Science Oxford

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Please use a persistent id in citations: doi:10.1016/j.polymer.2016.07.059

Abstract: By means of intramolecular folding/collapse of individual polymer chains (precursors), ultra-small soft nano-objects called single-chain nano-particles (SCNPs) can be synthesized. Here we present a combination of scattering techniques [small angle X-Ray and neutron scattering (SAXS and SANS), neutron spin echo (NSE) and dynamic light scattering (DLS)] to investigate the structure and dynamics of SCNPs in solution and their linear precursors as reference. Coarse-grained molecular dynamics (MD) simulations have also been carried out to complement this study. The application of SANS and SAXS has proved the compaction of the macromolecules upon creation of internal cross-links. However, the SCNPs obtained by different routes exhibit a far from globular topology in good solvent. Regarding the dynamics, we report on the first experimental investigation of the dynamic structure factor of SCNPs in solution. It reveals a clear impact of internal cross-links through (i) a reduction of the translational diffusion coefficient and (ii) an important slowing down of the internal modes. The data have been analyzed in terms of theoretical approximations based on the Zimm model. Both, structurally and dynamically, SCNPs show striking resemblances with intrinsically disordered proteins: similar scaling properties reflecting sparse morphologies and an extremely high internal friction.

Keyword(s): Polymers, Soft Nano Particles and Proteins (1st) ; Soft Condensed Matter (2nd)

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Contributing Institute(s):

1. JCNS-FRM-II (JCNS (München) ; Jülich Centre for Neutron Science JCNS (München) ; JCNS-FRM-II)
2. Neutronenstreuung (Neutronenstreuung ; JCNS-1)

Research Program(s):

1. 6G15 - FRM II / MLZ (POF3-6G15) (POF3-6G15)
2. 6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623) (POF3-623)

Experiment(s):

1. J-NSE: Neutron spin-echo spectrometer (NL2ao)
2. KWS-2: Small angle scattering diffractometer (NL3ao)

Appears in the scientific report 2016

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Database coverage:
; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; No Authors Fulltext ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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