Journal Article

FZJ-2016-07117

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Diagnostic potential of PET/CT using a $^{68}$Ga-labelled prostate-specific membrane antigen ligand in whole-body staging of renal cell carcinoma: initial experience

Sawicki, L. M. (Corresponding author) ; Buchbender, C. ; Boos, J. ; Giessing, M. ; Ermert, J.FZJ* ; Antke, C. ; Antoch, G. ; Hautzel, H.FZJ*

2017
Springer-Verl. Heidelberg [u.a.]

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Please use a persistent id in citations: doi:10.1007/s00259-016-3360-2

Abstract: Purpose To evaluate the diagnostic potential of whole-bodyPET/CT using a 68Ga-labelled PSMA ligand in renal cell carcinoma(RCC).Methods Six patients with histopathologically proven RCCunderwent 68Ga-PSMA PET/CT. Each PET/CT scan wasevaluated in relation to lesion count, location and dignity.SUVmax was measured in primary tumours and PETpositivemetastases. Tumour-to-background SUVmax ratios(TBRSUVmax) were calculated for primary RCCs in relationto the surrounding normal renal parenchyma. Metastasis-tobackgroundSUVmax ratios (MBRSUVmax) were calculatedfor PET-positive metastases in relation to gluteal muscle.Results Five primary RCCs and 16 metastases were evaluated.The mean SUVmax of the primary RCCs was 9.9 ± 9.2(range 1.7 – 27.2). Due to high uptake in the surrounding renalparenchyma, the mean TBRSUVmax of the primary RCCs wasonly 0.2 ± 0.3 (range 0.02 – 0.7). Eight metastases showed focal68Ga-PSMA uptake (SUVmax 9.9 ± 8.3, range 3.4 – 25.6).The mean MBRSUVmax of these PET-positive metastases was11.7 ± 0.2 (range 4.4 – 28.1). All PET-negative metastaseswere subcentimetre lung metastases.Conclusion 68Ga-PSMA PET/CT appears to be a promisingmethod for detecting RCC metastases. However, no additionaldiagnostic value in assessing the primary tumour was found.

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Contributing Institute(s):

1. Nuklearchemie (INM-5)
2. Klinisch-Medizinische Einrichtungen (Univ. Düsseldorf) (KME)

Research Program(s):

1. 572 - (Dys-)function and Plasticity (POF3-572) (POF3-572)

Appears in the scientific report 2017

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Database coverage:
; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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