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000824942 1001_ $$0P:(DE-Juel1)156548$$aUntiet, Verena$$b0
000824942 245__ $$aElevated Cytosolic Cl − Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons
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000824942 520__ $$aIn rodents, the vomeronasal system controls social and sexual behavior. However, several mechanistic aspects of sensory signaling in the vomeronasal organ remain unclear. Here, we investigate the biophysical basis of a recently proposed vomeronasal signal transduction component—a Ca 2+ -activated Cl − current. As the physiological role of such a current is a direct function of the Cl − equilibrium potential, we determined the intracellular Cl − concentration in dendritic knobs of vomeronasal neurons. Quantitative fluorescence lifetime imaging of a Cl − -sensitive dye at the apical surface of the intact vomeronasal neuroepithelium revealed increased cytosolic Cl − levels in dendritic knobs, a substantially lower Cl − concentration in vomeronasal sustentacular cells, and an apparent Cl − gradient in vomeronasal neurons along their dendritic apicobasal axis. Together, our data provide a biophysical basis for sensory signal amplification in vomeronasal neuron microvilli by opening Ca 2+ -activated Cl − channels. 
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000824942 7001_ $$0P:(DE-HGF)0$$aMoeller, Lisa M.$$b1
000824942 7001_ $$0P:(DE-HGF)0$$aIbarra-Soria, Ximena$$b2
000824942 7001_ $$0P:(DE-HGF)0$$aSánchez-Andrade, Gabriela$$b3
000824942 7001_ $$0P:(DE-HGF)0$$aStricker, Miriam$$b4
000824942 7001_ $$0P:(DE-HGF)0$$aNeuhaus, Eva M.$$b5
000824942 7001_ $$0P:(DE-HGF)0$$aLogan, Darren W.$$b6
000824942 7001_ $$0P:(DE-Juel1)131924$$aGensch, Thomas$$b7
000824942 7001_ $$0P:(DE-HGF)0$$aSpehr, Marc$$b8$$eCorresponding author
000824942 773__ $$0PERI:(DE-600)1494617-8$$a10.1093/chemse/bjw077$$gVol. 41, no. 8, p. 669 - 676$$n8$$p669 - 676$$tChemical senses$$v41$$x1464-3553$$y2016
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