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@ARTICLE{Untiet:824942,
      author       = {Untiet, Verena and Moeller, Lisa M. and Ibarra-Soria,
                      Ximena and Sánchez-Andrade, Gabriela and Stricker, Miriam
                      and Neuhaus, Eva M. and Logan, Darren W. and Gensch, Thomas
                      and Spehr, Marc},
      title        = {{E}levated {C}ytosolic {C}l − {C}oncentrations in
                      {D}endritic {K}nobs of {M}ouse {V}omeronasal {S}ensory
                      {N}eurons},
      journal      = {Chemical senses},
      volume       = {41},
      number       = {8},
      issn         = {1464-3553},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2016-07438},
      pages        = {669 - 676},
      year         = {2016},
      abstract     = {In rodents, the vomeronasal system controls social and
                      sexual behavior. However, several mechanistic aspects of
                      sensory signaling in the vomeronasal organ remain unclear.
                      Here, we investigate the biophysical basis of a recently
                      proposed vomeronasal signal transduction component—a Ca 2+
                      -activated Cl − current. As the physiological role of such
                      a current is a direct function of the Cl − equilibrium
                      potential, we determined the intracellular Cl −
                      concentration in dendritic knobs of vomeronasal neurons.
                      Quantitative fluorescence lifetime imaging of a Cl −
                      -sensitive dye at the apical surface of the intact
                      vomeronasal neuroepithelium revealed increased cytosolic Cl
                      − levels in dendritic knobs, a substantially lower Cl −
                      concentration in vomeronasal sustentacular cells, and an
                      apparent Cl − gradient in vomeronasal neurons along their
                      dendritic apicobasal axis. Together, our data provide a
                      biophysical basis for sensory signal amplification in
                      vomeronasal neuron microvilli by opening Ca 2+ -activated Cl
                      − channels.},
      cin          = {ICS-4},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-4-20110106},
      pnm          = {553 - Physical Basis of Diseases (POF3-553)},
      pid          = {G:(DE-HGF)POF3-553},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000384406500003},
      pubmed       = {pmid:27377750},
      doi          = {10.1093/chemse/bjw077},
      url          = {https://juser.fz-juelich.de/record/824942},
}