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| Home > Publications database > Cerebral uptake of FET after tumor resection in a F98 rat glioma model |
| Poster (Plenary/Keynote) | FZJ-2016-07748 |
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2015
Abstract: Objectives: In comparison with morphological MRI, PET using the amino acid O-(2-[F-18]fluoroethyl)-L-tyrosine (FET) allows an improved delineation of tumor tissue from benign tissue reactions. However, unspecific uptake of FET was observed in non-neoplastic brain lesions and in areas of reactive astrogliosis in experimental studies. The surgical resection of a tumor might induce tissue responses that potentially could lead to an unspecific accumulation of FET, and might falsely be interpreted as residual tumor tissue. Therefore, the intracerebral FET uptake after tumor resection in a F98 rat glioma model was examined.Methods: F98 gliomas were implanted into the cerebral cortex of 21 male Fischer 344 rats and resected after 7 days of tumor growth. After 2, 3, 7 or 14 days of surgery, FET was administered intravenously into the tail vein. Within 1 h after injection, coronal cryosections of the brains were produced and evaluated by FET autoradiography and histological stainings. Cerebral FET uptake was quantified by lesion to brain (L/B) or tumor to brain (T/B) ratios and compared with data on tumoral FET uptake in human glioblastomas.Results: After tumor resection, all animals exhibited a slightly increased unspecific uptake of FET in the peritumoral area of resection. A maximum of unspecific FET uptake could be observed 3 days after surgery (L/B: 1.94 ± 0.26) which decreased significantly after 7-14 days (L/B: 1.57-1.39 ± 0.23-0.18; p<0.05). Compared to data on FET uptake in human glioblastomas, FET demonstrated a significant lower unspecific uptake in the vicinity of the surgical defect from the 7th day after surgery. At each time point, F98 rat tumors exhibited a significant higher tumoral FET uptake (4.4 ± 0.8; p<0.05) and could be separated from unspecific FET uptake in the vicinity of the resection area.Conclusions: The results of this study demonstrate that the surgical resection of a tumor in rats causes a slightly increased uptake of FET in the vicinity of the resection area that can be clearly separated from tumor tissue. From the 7th day after surgery, unspecific FET uptake decreased significantly in rats and was significantly lower than that observed in human glioblastomas.Thus, it can be assumed that the correct identification of residual tumor tissue by FET PET and the planning of postoperative radiotherapy appear to be only less affected by unspecific FET uptake later than 7 days after tumor resection.
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