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@INPROCEEDINGS{Geisler:825277,
      author       = {Geisler, Stefanie and Ermert, Johannes and Rapp, Marion and
                      Willuweit, Antje and Sabel, Michael and Coenen, Heinrich
                      Hubert and Shah, N. J. and Langen, Karl-Josef},
      title        = {{C}erebral uptake of {FET} after tumor resection in a {F}98
                      rat glioma model},
      reportid     = {FZJ-2016-07748},
      year         = {2015},
      abstract     = {Objectives: In comparison with morphological MRI, PET using
                      the amino acid O-(2-[F-18]fluoroethyl)-L-tyrosine (FET)
                      allows an improved delineation of tumor tissue from benign
                      tissue reactions. However, unspecific uptake of FET was
                      observed in non-neoplastic brain lesions and in areas of
                      reactive astrogliosis in experimental studies. The surgical
                      resection of a tumor might induce tissue responses that
                      potentially could lead to an unspecific accumulation of FET,
                      and might falsely be interpreted as residual tumor tissue.
                      Therefore, the intracerebral FET uptake after tumor
                      resection in a F98 rat glioma model was examined.Methods:
                      F98 gliomas were implanted into the cerebral cortex of 21
                      male Fischer 344 rats and resected after 7 days of tumor
                      growth. After 2, 3, 7 or 14 days of surgery, FET was
                      administered intravenously into the tail vein. Within 1 h
                      after injection, coronal cryosections of the brains were
                      produced and evaluated by FET autoradiography and
                      histological stainings. Cerebral FET uptake was quantified
                      by lesion to brain (L/B) or tumor to brain (T/B) ratios and
                      compared with data on tumoral FET uptake in human
                      glioblastomas.Results: After tumor resection, all animals
                      exhibited a slightly increased unspecific uptake of FET in
                      the peritumoral area of resection. A maximum of unspecific
                      FET uptake could be observed 3 days after surgery (L/B: 1.94
                      ± 0.26) which decreased significantly after 7-14 days (L/B:
                      1.57-1.39 ± 0.23-0.18; p<0.05). Compared to data on FET
                      uptake in human glioblastomas, FET demonstrated a
                      significant lower unspecific uptake in the vicinity of the
                      surgical defect from the 7th day after surgery. At each time
                      point, F98 rat tumors exhibited a significant higher tumoral
                      FET uptake (4.4 ± 0.8; p<0.05) and could be separated from
                      unspecific FET uptake in the vicinity of the resection
                      area.Conclusions: The results of this study demonstrate that
                      the surgical resection of a tumor in rats causes a slightly
                      increased uptake of FET in the vicinity of the resection
                      area that can be clearly separated from tumor tissue. From
                      the 7th day after surgery, unspecific FET uptake decreased
                      significantly in rats and was significantly lower than that
                      observed in human glioblastomas.Thus, it can be assumed that
                      the correct identification of residual tumor tissue by FET
                      PET and the planning of postoperative radiotherapy appear to
                      be only less affected by unspecific FET uptake later than 7
                      days after tumor resection.},
      month         = {May},
      date          = {2015-05-26},
      organization  = {21st International Symposium on
                       Radiopharmaceutical Sciences, Columbia
                       (USA), 26 May 2015 - 31 May 2015},
      subtyp        = {Plenary/Keynote},
      cin          = {INM-4 / INM-5},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-5-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)24},
      url          = {https://juser.fz-juelich.de/record/825277},
}