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@ARTICLE{Foglia:827561,
      author       = {Foglia, Fabrizia and Hazael, Rachael and Simeoni, Giovanna
                      G. and Appavou, Marie-Sousai and Moulin, Martine and
                      Haertlein, Michael and Trevor Forsyth, V. and Seydel, Tilo
                      and Daniel, Isabelle and Meersman, Filip and McMillan, Paul
                      F.},
      title        = {{W}ater {D}ynamics in {S}hewanella oneidensis at {A}mbient
                      and {H}igh {P}ressure using {Q}uasi-{E}lastic {N}eutron
                      {S}cattering},
      journal      = {Scientific reports},
      volume       = {6},
      issn         = {2045-2322},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2017-01681},
      pages        = {18862 -},
      year         = {2016},
      abstract     = {Quasielastic neutron scattering (QENS) is an ideal
                      technique for studying water transport and relaxation
                      dynamics at pico- to nanosecond timescales and at length
                      scales relevant to cellular dimensions. Studies of high
                      pressure dynamic effects in live organisms are needed to
                      understand Earth’s deep biosphere and biotechnology
                      applications. Here we applied QENS to study water transport
                      in Shewanella oneidensis at ambient (0.1 MPa) and high (200
                      MPa) pressure using H/D isotopic contrast experiments for
                      normal and perdeuterated bacteria and buffer solutions to
                      distinguish intracellular and transmembrane processes. The
                      results indicate that intracellular water dynamics are
                      comparable with bulk diffusion rates in aqueous fluids at
                      ambient conditions but a significant reduction occurs in
                      high pressure mobility. We interpret this as due to enhanced
                      interactions with macromolecules in the nanoconfined
                      environment. Overall diffusion rates across the cell
                      envelope also occur at similar rates but unexpected
                      narrowing of the QENS signal appears between momentum
                      transfer values Q = 0.7–1.1 Å−1 corresponding to
                      real space dimensions of 6–9 Å. The relaxation time
                      increase can be explained by correlated dynamics of
                      molecules passing through Aquaporin water transport
                      complexes located within the inner or outer membrane
                      structures.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {000},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
                      / 6G15 - FRM II / MLZ (POF3-6G15) / NMI3-II - Neutron
                      Scattering and Muon Spectroscopy Integrated Initiative
                      (283883)},
      pid          = {G:(DE-HGF)POF3-6G4 / G:(DE-HGF)POF3-6G15 /
                      G:(EU-Grant)283883},
      experiment   = {EXP:(DE-MLZ)TOF-TOF-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000368191200001},
      pubmed       = {pmid:26738409},
      doi          = {10.1038/srep18862},
      url          = {https://juser.fz-juelich.de/record/827561},
}