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@ARTICLE{Wolff:829628,
      author       = {Wolff, Martin and Zhang-Haagen, Bo and Decker, Christina
                      and Barz, Bogdan and Schneider, Mario and Biehl, Ralf and
                      Radulescu, Aurel and Strodel, Birgit and Willbold, Dieter
                      and Nagel-Steger, Luitgard},
      title        = {{A}β42 pentamers/hexamers are the smallest detectable
                      oligomers in solution},
      journal      = {Scientific reports},
      volume       = {7},
      issn         = {2045-2322},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2017-03297},
      pages        = {2493},
      year         = {2017},
      abstract     = {Amyloid β (Aβ) oligomers may play a decisive role in
                      Alzheimer’s disease related neurodegeneration, but their
                      structural properties are poorly understood. In this report,
                      sedimentation velocity centrifugation, small angle neutron
                      scattering (SANS) and molecular modelling were used to
                      identify the small oligomeric species formed by the 42 amino
                      acid residue long isoform of Aβ (Aβ42) in solution,
                      characterized by a sedimentation coefficient of 2.56 S,
                      and a radius of gyration between 2 and 4 nm. The measured
                      sedimentation coefficient is in close agreement with the
                      sedimentation coefficient calculated for Aβ42 hexamers
                      using MD simulations at µM concentration. To the best of
                      our knowledge this is the first report detailing the Aβ42
                      oligomeric species by SANS measurements. Our results
                      demonstrate that the smallest detectable species in solution
                      are penta- to hexamers. No evidences for the presence of
                      dimers, trimers or tetramers were found, although the
                      existence of those Aβ42 oligomers at measurable quantities
                      had been reported frequently.},
      cin          = {ICS-6},
      ddc          = {000},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {553 - Physical Basis of Diseases (POF3-553)},
      pid          = {G:(DE-HGF)POF3-553},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000402310900006},
      pubmed       = {pmid:28559586},
      doi          = {10.1038/s41598-017-02370-3},
      url          = {https://juser.fz-juelich.de/record/829628},
}