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@ARTICLE{Farrher:829732,
author = {Farrher, Ezequiel and Lindemeyer, Johannes and Grinberg,
Farida and Oros-Peusquens, Ana-Maria and Shah, N. J.},
title = {{C}oncerning the matching of magnetic susceptibility
differences for the compensation of background gradients in
anisotropic diffusion fibre phantoms},
journal = {PLoS one},
volume = {12},
number = {5},
issn = {1932-6203},
address = {Lawrence, Kan.},
publisher = {PLoS},
reportid = {FZJ-2017-03370},
pages = {e0176192 -},
year = {2017},
abstract = {Artificial, anisotropic fibre phantoms are nowadays
increasingly used in the field of diffusion-weighted MRI.
Such phantoms represent useful tools for, among others, the
calibration of pulse sequences and validation of diffusion
models since they can mimic well-known structural features
of brain tissue on the one hand, but exhibit a reduced
complexity, on the other. Among all materials, polyethylene
fibres have been widely used due to their excellent
properties regarding the restriction of water diffusion and
surface relaxation properties. Yet the magnetic
susceptibility of polyethylene can be distinctly lower than
that of distilled water. This difference produces strong
microscopic, background field gradients in the vicinity of
fibre bundles which are not parallel to the static magnetic
field. This, in turn, modulates the MRI signal behaviour. In
the present work we investigate an approach to reduce the
susceptibility-induced background gradients via reducing the
heterogeneity in the internal magnetic susceptibility. An
aqueous solution of magnesium chloride hexahydrate
(MgCl2·6H2O) is used for this purpose. Its performance is
demonstrated in dedicated anisotropic fibre phantoms with
different geometrical configurations.},
cin = {INM-4 / JARA-BRAIN},
ddc = {500},
cid = {I:(DE-Juel1)INM-4-20090406 / $I:(DE-82)080010_20140620$},
pnm = {573 - Neuroimaging (POF3-573)},
pid = {G:(DE-HGF)POF3-573},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000400647000043},
pubmed = {pmid:28467458},
doi = {10.1371/journal.pone.0176192},
url = {https://juser.fz-juelich.de/record/829732},
}