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@ARTICLE{Blenau:829982,
      author       = {Blenau, Wolfgang and Daniel, Stöppler and Balfanz, Sabine
                      and Thamm, Markus and Baumann, A.},
      title        = {{D}m5-{HT}$_{2{B}}$: {P}harmacological {C}haracterization
                      of the {F}ifth {S}erotonin {R}eceptor {S}ubtype of
                      {D}rosophila melanogaster},
      journal      = {Frontiers in systems neuroscience},
      volume       = {11},
      issn         = {1662-5137},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2017-03584},
      pages        = {28},
      year         = {2017},
      abstract     = {Serotonin (5-hydroxytryptamine, 5-HT) is an important
                      regulator of physiological and behavioral processes in both
                      protostomes (e.g., insects) and deuterostomes (e.g.,
                      mammals). In insects, serotonin has been found to modulate
                      the heart rate and to control secretory processes,
                      development, circadian rhythms, aggressive behavior, as well
                      as to contribute to learning and memory. Serotonin exerts
                      its activity by binding to and activating specific membrane
                      receptors. The clear majority of these receptors belong to
                      the superfamily of G-protein-coupled receptors. In
                      Drosophila melanogaster, a total of five genes have been
                      identified coding for 5-HT receptors. From this family of
                      proteins, four have been pharmacologically examined in
                      greater detail, so far. While Dm5-HT1A, Dm5-HT1B, and
                      Dm5-HT7 couple to cAMP signaling cascades, the Dm5-HT2A
                      receptor leads to Ca2+ signaling in an
                      inositol-1,4,5-trisphosphate-dependent manner. Based on
                      sequence similarity to homologous genes in other insects, a
                      fifth D. melanogaster gene was uncovered coding for a
                      Dm5-HT2B receptor. Knowledge about this receptor’s
                      pharmacological properties is very limited. This is quite
                      surprising because Dm5-HT2B has been attributed to distinct
                      physiological functions based on genetic interference with
                      its gene expression. Mutations were described reducing the
                      response of the larval heart to 5-HT, and specific knockdown
                      of Dm5-HT2B mRNA in hemocytes resulted in a higher
                      susceptibility of the flies to bacterial infection. To gain
                      deeper understanding of Dm5-HT2B’s pharmacology, we
                      evaluated the receptor’s response to a series of
                      established 5-HT receptor agonists and antagonists in a
                      functional cell-based assay. Metoclopramide and mianserin
                      were identified as two potent antagonists that may allow
                      pharmacological interference with Dm5-HT2B signaling in
                      vitro and in vivo.},
      cin          = {ICS-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ICS-4-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000401656800002},
      pubmed       = {pmid:28553207},
      doi          = {10.3389/fnsys.2017.00028},
      url          = {https://juser.fz-juelich.de/record/829982},
}