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000836104 1001_ $$0P:(DE-HGF)0$$aHundshammer, Christian$$b0
000836104 245__ $$aDeuteration of hyperpolarized 13 c-labelled zymonic and enables sensitivity-enhanced dynamic MRI of pH
000836104 260__ $$aWeinheim$$bWiley-VCH Verl.$$c2017
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000836104 520__ $$aAberrant pH is characteristic of many pathologies such as ischemia, inflammation or cancer. Therefore, a non-invasive and spatially resolved pH determination is valuable for disease diagnosis, characterization of response to treatment and the design of pH-sensitive drug-delivery systems. We recently introduced hyperpolarized [1,5-13C2]zymonic acid (ZA) as a novel MRI probe of extracellular pH utilizing dissolution dynamic polarization (DNP) for a more than 10000-fold signal enhancement of the MRI signal. Here we present a strategy to enhance the sensitivity of this approach by deuteration of ZA yielding [1,5-13C2, 3,6,6,6-D4]zymonic acid (ZAd), which prolongs the liquid state spin lattice relaxation time (T1) by up to 39 % in vitro. Measurements with ZA and ZAd on subcutaneous MAT B III adenocarcinoma in rats show that deuteration increases the signal-to-noise ratio (SNR) by up to 46 % in vivo. Furthermore, we demonstrate a proof of concept for real-time imaging of dynamic pH changes in vitro using ZAd, potentially allowing for the characterization of rapid acidification/basification processes in vivo.
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000836104 7001_ $$0P:(DE-HGF)0$$aDüwel, Stephan$$b1
000836104 7001_ $$0P:(DE-Juel1)192562$$aKöcher, Simone Swantje$$b2
000836104 7001_ $$0P:(DE-HGF)0$$aGersch, Malte$$b3
000836104 7001_ $$0P:(DE-HGF)0$$aFeuerecker, Benedikt$$b4
000836104 7001_ $$0P:(DE-HGF)0$$aScheurer, Christoph$$b5
000836104 7001_ $$0P:(DE-HGF)0$$aHaase, Axel$$b6
000836104 7001_ $$0P:(DE-HGF)0$$aGlaser, Steffen J.$$b7
000836104 7001_ $$0P:(DE-HGF)0$$aSchwaiger, Markus$$b8
000836104 7001_ $$0P:(DE-HGF)0$$aSchilling, Franz$$b9$$eCorresponding author
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