Journal Article

FZJ-2017-05228

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Deuteration of hyperpolarized 13 c-labelled zymonic and enables sensitivity-enhanced dynamic MRI of pH

Hundshammer, C.TUM* ; Düwel, S.TUM* ; Köcher, S. S.FZJ*TUM* ; Gersch, M.TUM* ; Feuerecker, B.TUM* ; Scheurer, C.TUM* ; Haase, A.TUM* ; Glaser, S. J. ; Schwaiger, M.TUM* ; Schilling, F. (Corresponding author)

2017
Wiley-VCH Verl. Weinheim

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Please use a persistent id in citations: doi:10.1002/cphc.201700779

Abstract: Aberrant pH is characteristic of many pathologies such as ischemia, inflammation or cancer. Therefore, a non-invasive and spatially resolved pH determination is valuable for disease diagnosis, characterization of response to treatment and the design of pH-sensitive drug-delivery systems. We recently introduced hyperpolarized [1,5-13C2]zymonic acid (ZA) as a novel MRI probe of extracellular pH utilizing dissolution dynamic polarization (DNP) for a more than 10000-fold signal enhancement of the MRI signal. Here we present a strategy to enhance the sensitivity of this approach by deuteration of ZA yielding [1,5-13C2, 3,6,6,6-D4]zymonic acid (ZAd), which prolongs the liquid state spin lattice relaxation time (T1) by up to 39 % in vitro. Measurements with ZA and ZAd on subcutaneous MAT B III adenocarcinoma in rats show that deuteration increases the signal-to-noise ratio (SNR) by up to 46 % in vivo. Furthermore, we demonstrate a proof of concept for real-time imaging of dynamic pH changes in vitro using ZAd, potentially allowing for the characterization of rapid acidification/basification processes in vivo.

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Contributing Institute(s):

1. Grundlagen der Elektrochemie (IEK-9)

Research Program(s):

1. 131 - Electrochemical Storage (POF3-131) (POF3-131)
2. HITEC - Helmholtz Interdisciplinary Doctoral Training in Energy and Climate Research (HITEC) (HITEC-20170406) (HITEC-20170406)

Appears in the scientific report 2018

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Database coverage:
; Current Contents - Physical, Chemical and Earth Sciences ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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