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@ARTICLE{Hundshammer:836104,
      author       = {Hundshammer, Christian and Düwel, Stephan and Köcher,
                      Simone Swantje and Gersch, Malte and Feuerecker, Benedikt
                      and Scheurer, Christoph and Haase, Axel and Glaser, Steffen
                      J. and Schwaiger, Markus and Schilling, Franz},
      title        = {{D}euteration of hyperpolarized 13 c-labelled zymonic and
                      enables sensitivity-enhanced dynamic {MRI} of p{H}},
      journal      = {ChemPhysChem},
      volume       = {18},
      number       = {18},
      issn         = {1439-4235},
      address      = {Weinheim},
      publisher    = {Wiley-VCH Verl.},
      reportid     = {FZJ-2017-05228},
      pages        = {2422–2425},
      year         = {2017},
      abstract     = {Aberrant pH is characteristic of many pathologies such as
                      ischemia, inflammation or cancer. Therefore, a non-invasive
                      and spatially resolved pH determination is valuable for
                      disease diagnosis, characterization of response to treatment
                      and the design of pH-sensitive drug-delivery systems. We
                      recently introduced hyperpolarized [1,5-13C2]zymonic acid
                      (ZA) as a novel MRI probe of extracellular pH utilizing
                      dissolution dynamic polarization (DNP) for a more than
                      10000-fold signal enhancement of the MRI signal. Here we
                      present a strategy to enhance the sensitivity of this
                      approach by deuteration of ZA yielding [1,5-13C2,
                      3,6,6,6-D4]zymonic acid (ZAd), which prolongs the liquid
                      state spin lattice relaxation time (T1) by up to $39 \%$
                      in vitro. Measurements with ZA and ZAd on subcutaneous MAT
                      B III adenocarcinoma in rats show that deuteration increases
                      the signal-to-noise ratio (SNR) by up to $46 \%$
                      in vivo. Furthermore, we demonstrate a proof of concept
                      for real-time imaging of dynamic pH changes in vitro using
                      ZAd, potentially allowing for the characterization of rapid
                      acidification/basification processes in vivo.},
      cin          = {IEK-9},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IEK-9-20110218},
      pnm          = {131 - Electrochemical Storage (POF3-131) / HITEC -
                      Helmholtz Interdisciplinary Doctoral Training in Energy and
                      Climate Research (HITEC) (HITEC-20170406)},
      pid          = {G:(DE-HGF)POF3-131 / G:(DE-Juel1)HITEC-20170406},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28719100},
      UT           = {WOS:000411193200001},
      doi          = {10.1002/cphc.201700779},
      url          = {https://juser.fz-juelich.de/record/836104},
}