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| Hauptseite > Publikationsdatenbank > Deuteration of hyperpolarized 13 c-labelled zymonic and enables sensitivity-enhanced dynamic MRI of pH > print |
| Hauptseite > Publikationsdatenbank > Deuteration of hyperpolarized 13 c-labelled zymonic and enables sensitivity-enhanced dynamic MRI of pH > print |
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| 024 | 7 | _ | |a 10.1002/cphc.201700779 |2 doi |
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| 100 | 1 | _ | |0 P:(DE-HGF)0 |a Hundshammer, Christian |b 0 |
| 245 | _ | _ | |a Deuteration of hyperpolarized 13 c-labelled zymonic and enables sensitivity-enhanced dynamic MRI of pH |
| 260 | _ | _ | |a Weinheim |b Wiley-VCH Verl. |c 2017 |
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| 520 | _ | _ | |a Aberrant pH is characteristic of many pathologies such as ischemia, inflammation or cancer. Therefore, a non-invasive and spatially resolved pH determination is valuable for disease diagnosis, characterization of response to treatment and the design of pH-sensitive drug-delivery systems. We recently introduced hyperpolarized [1,5-13C2]zymonic acid (ZA) as a novel MRI probe of extracellular pH utilizing dissolution dynamic polarization (DNP) for a more than 10000-fold signal enhancement of the MRI signal. Here we present a strategy to enhance the sensitivity of this approach by deuteration of ZA yielding [1,5-13C2, 3,6,6,6-D4]zymonic acid (ZAd), which prolongs the liquid state spin lattice relaxation time (T1) by up to 39 % in vitro. Measurements with ZA and ZAd on subcutaneous MAT B III adenocarcinoma in rats show that deuteration increases the signal-to-noise ratio (SNR) by up to 46 % in vivo. Furthermore, we demonstrate a proof of concept for real-time imaging of dynamic pH changes in vitro using ZAd, potentially allowing for the characterization of rapid acidification/basification processes in vivo. |
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| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Düwel, Stephan |b 1 |
| 700 | 1 | _ | |0 P:(DE-Juel1)192562 |a Köcher, Simone Swantje |b 2 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Gersch, Malte |b 3 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Feuerecker, Benedikt |b 4 |
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| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Haase, Axel |b 6 |
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| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Schwaiger, Markus |b 8 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Schilling, Franz |b 9 |e Corresponding author |
| 773 | _ | _ | |0 PERI:(DE-600)2025223-7 |a 10.1002/cphc.201700779 |n 18 |p 2422–2425 |t ChemPhysChem |v 18 |x 1439-4235 |y 2017 |
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