Journal Article

FZJ-2017-06350

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Positron emission tomography imaging in diffuse intrinsic pontine gliomaINM

Galldiks, N. (Corresponding author)FZJ* ; Stegmayr, C.FZJ* ; Willuweit, A.FZJ* ; Langen, K.-J.FZJ*

2017
AME Publishing Company Shatin, NT

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Please use a persistent id in citations: doi:10.21037/atm.2017.05.02

Abstract: In pediatric patients with brain tumors, both the monitoring of brain tumor therapy and evaluation of treatment response is of paramount importance (1). In particular, the early identification of non-response allows the termination of an ineffective therapy to avoid possible side effects (e.g., bone marrow depression, nausea, fatigue, allergies, and polyneuropathy) and therefore to maintain or even improve life-quality. Furthermore, the early identification of non-response allows an earlier treatment change. For example, in the event of chemotherapy failure, negative side effects can be avoided and an earlier switch to another chemotherapeutic agent is possible before bone marrow reserves are exhausted. Moreover, identification of treatment failure may help reduce costs. To date, this is highly relevant because the expense of newer systemic treatment options (e.g., immunotherapy and targeted therapy options such as tyrosine kinase inhibitors, BRAF inhibitors, and MEK inhibitors) is considerably higher than conventional alkylating chemotherapy.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)
2. Physik der Medizinischen Bildgebung (INM-4)

Research Program(s):

1. 573 - Neuroimaging (POF3-573) (POF3-573)

Appears in the scientific report 2017

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Database coverage:
; NCBI Molecular Biology Database

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