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@ARTICLE{Vitiello:838018,
      author       = {Vitiello, Giuseppe and Musumeci, Domenica and Koutsioumpas,
                      Alexandros and Paduano, Luigi and Montesarchio, Daniela and
                      D'Errico, Gerardino},
      title        = {{I}onophores at work: {E}xploring the interaction of
                      guanosine-based amphiphiles with phospholipid membranes},
      journal      = {Biochimica et biophysica acta / Biomembranes},
      volume       = {1859},
      number       = {12},
      issn         = {0005-2736},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {FZJ-2017-06761},
      pages        = {2392 - 2401},
      year         = {2017},
      abstract     = {An amphiphilic derivative of guanosine, carrying a
                      myristoyl group at the 5′-position and two
                      methoxy(triethylene glycol) appendages at the 2′ and
                      3′-positions (1), endowed with high ionophoric activity,
                      has been here studied in its interaction mode with a model
                      lipid membrane along with its 5′-spin-labelled analogue 2,
                      bearing the 5-doxyl-stearic in lieu of the myristic residue.
                      Electron spin resonance spectra, carried out on the
                      spin-labelled nucleolipid 2 in mixture with a DOPC/DOPG
                      phospholipid bilayer, on one side, and on spin-labelled
                      lipids mixed with 1, on the other, integrated with dynamic
                      light scattering and neutron reflectivity measurements,
                      allowed getting an in-depth picture of the effect of the
                      ionophores on membrane structure, relevant to clarify the
                      ion transport mechanism through lipid bilayers.
                      Particularly, dehydration of lipid headgroups and lowering
                      of both the local polarity and acyl chains order across the
                      bilayer, due to the insertion of the oligo(ethylene glycol)
                      chains in the bilayer hydrophobic core, have been found to
                      be the main effects of the amphiphilic guanosines
                      interaction with the membrane. These results furnish
                      directions to rationally implement future ionophores
                      design.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)MARIA-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28890186},
      UT           = {WOS:000415770900012},
      doi          = {10.1016/j.bbamem.2017.09.007},
      url          = {https://juser.fz-juelich.de/record/838018},
}