Home > Publications database > Ionophores at work: Exploring the interaction of guanosine-based amphiphiles with phospholipid membranes > print

001     838018
005     20210129231457.0
024 7 _ |a 10.1016/j.bbamem.2017.09.007
|2 doi
024 7 _ |a 0005-2736
|2 ISSN
024 7 _ |a 1879-2642
|2 ISSN
024 7 _ |a 2128/15929
|2 Handle
024 7 _ |a pmid:28890186
|2 pmid
024 7 _ |a WOS:000415770900012
|2 WOS
024 7 _ |a altmetric:25052921
|2 altmetric
037 _ _ |a FZJ-2017-06761
082 _ _ |a 570
100 1 _ |a Vitiello, Giuseppe
|0 P:(DE-HGF)0
|b 0
245 _ _ |a Ionophores at work: Exploring the interaction of guanosine-based amphiphiles with phospholipid membranes
260 _ _ |a Amsterdam
|c 2017
|b Elsevier
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1511448320_4950
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a An amphiphilic derivative of guanosine, carrying a myristoyl group at the 5′-position and two methoxy(triethylene glycol) appendages at the 2′ and 3′-positions (1), endowed with high ionophoric activity, has been here studied in its interaction mode with a model lipid membrane along with its 5′-spin-labelled analogue 2, bearing the 5-doxyl-stearic in lieu of the myristic residue. Electron spin resonance spectra, carried out on the spin-labelled nucleolipid 2 in mixture with a DOPC/DOPG phospholipid bilayer, on one side, and on spin-labelled lipids mixed with 1, on the other, integrated with dynamic light scattering and neutron reflectivity measurements, allowed getting an in-depth picture of the effect of the ionophores on membrane structure, relevant to clarify the ion transport mechanism through lipid bilayers. Particularly, dehydration of lipid headgroups and lowering of both the local polarity and acyl chains order across the bilayer, due to the insertion of the oligo(ethylene glycol) chains in the bilayer hydrophobic core, have been found to be the main effects of the amphiphilic guanosines interaction with the membrane. These results furnish directions to rationally implement future ionophores design.
536 _ _ |0 G:(DE-HGF)POF3-6G15
|f POF III
|x 0
|c POF3-6G15
|a 6G15 - FRM II / MLZ (POF3-6G15)
536 _ _ |a 6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
|0 G:(DE-HGF)POF3-6G4
|c POF3-623
|f POF III
|x 1
588 _ _ |a Dataset connected to CrossRef
650 2 7 |a Soft Condensed Matter
|0 V:(DE-MLZ)SciArea-210
|2 V:(DE-HGF)
|x 0
650 2 7 |a Biology
|0 V:(DE-MLZ)SciArea-160
|2 V:(DE-HGF)
|x 1
650 1 7 |a Health and Life
|0 V:(DE-MLZ)GC-130-2016
|2 V:(DE-HGF)
|x 0
693 _ _ |a Forschungs-Neutronenquelle Heinz Maier-Leibnitz
|e MARIA: Magnetic reflectometer with high incident angle
|f NL5N
|1 EXP:(DE-MLZ)FRMII-20140101
|0 EXP:(DE-MLZ)MARIA-20140101
|5 EXP:(DE-MLZ)MARIA-20140101
|6 EXP:(DE-MLZ)NL5N-20140101
|x 0
700 1 _ |a Musumeci, Domenica
|0 P:(DE-HGF)0
|b 1
700 1 _ |a Koutsioumpas, Alexandros
|0 P:(DE-Juel1)158075
|b 2
700 1 _ |a Paduano, Luigi
|0 P:(DE-HGF)0
|b 3
700 1 _ |a Montesarchio, Daniela
|0 P:(DE-HGF)0
|b 4
|e Corresponding author
700 1 _ |a D'Errico, Gerardino
|0 P:(DE-HGF)0
|b 5
|e Corresponding author
773 _ _ |a 10.1016/j.bbamem.2017.09.007
|g Vol. 1859, no. 12, p. 2392 - 2401
|0 PERI:(DE-600)2209384-9
|n 12
|p 2392 - 2401
|t Biochimica et biophysica acta / Biomembranes
|v 1859
|y 2017
|x 0005-2736
856 4 _ |u https://juser.fz-juelich.de/record/838018/files/1-s2.0-S000527361730281X-main.pdf
|y Restricted
856 4 _ |y Published on 2017-09-08. Available in OpenAccess from 2018-09-08.
|z StatID:(DE-HGF)0510
|u https://juser.fz-juelich.de/record/838018/files/manuscript-errico.pdf
856 4 _ |x icon
|u https://juser.fz-juelich.de/record/838018/files/1-s2.0-S000527361730281X-main.gif?subformat=icon
|y Restricted
856 4 _ |x icon-1440
|u https://juser.fz-juelich.de/record/838018/files/1-s2.0-S000527361730281X-main.jpg?subformat=icon-1440
|y Restricted
856 4 _ |x icon-180
|u https://juser.fz-juelich.de/record/838018/files/1-s2.0-S000527361730281X-main.jpg?subformat=icon-180
|y Restricted
856 4 _ |x icon-640
|u https://juser.fz-juelich.de/record/838018/files/1-s2.0-S000527361730281X-main.jpg?subformat=icon-640
|y Restricted
856 4 _ |x pdfa
|u https://juser.fz-juelich.de/record/838018/files/1-s2.0-S000527361730281X-main.pdf?subformat=pdfa
|y Restricted
856 4 _ |y Published on 2017-09-08. Available in OpenAccess from 2018-09-08.
|x icon
|z StatID:(DE-HGF)0510
|u https://juser.fz-juelich.de/record/838018/files/manuscript-errico.gif?subformat=icon
856 4 _ |y Published on 2017-09-08. Available in OpenAccess from 2018-09-08.
|x icon-1440
|z StatID:(DE-HGF)0510
|u https://juser.fz-juelich.de/record/838018/files/manuscript-errico.jpg?subformat=icon-1440
856 4 _ |y Published on 2017-09-08. Available in OpenAccess from 2018-09-08.
|x icon-180
|z StatID:(DE-HGF)0510
|u https://juser.fz-juelich.de/record/838018/files/manuscript-errico.jpg?subformat=icon-180
856 4 _ |y Published on 2017-09-08. Available in OpenAccess from 2018-09-08.
|x icon-640
|z StatID:(DE-HGF)0510
|u https://juser.fz-juelich.de/record/838018/files/manuscript-errico.jpg?subformat=icon-640
856 4 _ |y Published on 2017-09-08. Available in OpenAccess from 2018-09-08.
|x pdfa
|z StatID:(DE-HGF)0510
|u https://juser.fz-juelich.de/record/838018/files/manuscript-errico.pdf?subformat=pdfa
909 C O |o oai:juser.fz-juelich.de:838018
|p openaire
|p VDB:MLZ
|p driver
|p open_access
|p VDB
|p dnbdelivery
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 2
|6 P:(DE-Juel1)158075
913 1 _ |a DE-HGF
|9 G:(DE-HGF)POF3-6G15
|x 0
|4 G:(DE-HGF)POF
|v FRM II / MLZ
|1 G:(DE-HGF)POF3-6G0
|0 G:(DE-HGF)POF3-6G15
|3 G:(DE-HGF)POF3
|2 G:(DE-HGF)POF3-600
|b Forschungsbereich Materie
|l Großgeräte: Materie
913 1 _ |a DE-HGF
|b Forschungsbereich Materie
|l Von Materie zu Materialien und Leben
|1 G:(DE-HGF)POF3-620
|0 G:(DE-HGF)POF3-623
|2 G:(DE-HGF)POF3-600
|v Facility topic: Neutrons for Research on Condensed Matter
|9 G:(DE-HGF)POF3-6G4
|x 1
|4 G:(DE-HGF)POF
|3 G:(DE-HGF)POF3
914 1 _ |y 2017
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
915 _ _ |a Embargoed OpenAccess
|0 StatID:(DE-HGF)0530
|2 StatID
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b BBA-BIOMEMBRANES : 2015
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
915 _ _ |a WoS
|0 StatID:(DE-HGF)0110
|2 StatID
|b Science Citation Index
915 _ _ |a WoS
|0 StatID:(DE-HGF)0111
|2 StatID
|b Science Citation Index Expanded
915 _ _ |a IF < 5
|0 StatID:(DE-HGF)9900
|2 StatID
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
915 _ _ |a Nationallizenz
|0 StatID:(DE-HGF)0420
|2 StatID
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Thomson Reuters Master Journal List
920 _ _ |l yes
920 1 _ |0 I:(DE-Juel1)JCNS-FRM-II-20110218
|k JCNS (München) ; Jülich Centre for Neutron Science JCNS (München) ; JCNS-FRM-II
|l JCNS-FRM-II
|x 0
920 1 _ |0 I:(DE-Juel1)JCNS-1-20110106
|k Neutronenstreuung ; JCNS-1
|l Neutronenstreuung
|x 1
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-Juel1)JCNS-FRM-II-20110218
980 _ _ |a I:(DE-Juel1)JCNS-1-20110106
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21