TY  - JOUR
AU  - Mangiapia, Gaetano
AU  - Gvaramia, Manuchar
AU  - Kuhrts, Lucas
AU  - Teixeira, Jose
AU  - Soltwedel, Olaf
AU  - Frielinghaus, Henrich
AU  - Koutsioumpas, Alexandros
TI  - Effect of Benzocaine and Propranolol on phospholipid-based bilayers
JO  - Physical chemistry, chemical physics
VL  - 19
IS  - 47
SN  - 1463-9084
CY  - Cambridge
PB  - RSC Publ.
M1  - FZJ-2017-07353
SP  - 32057-32071
PY  - 2017
AB  - Cell membranes play a fundamental role in protecting the cell from its surroundings, in addition to host many proteins with fundamental biological tasks. A study of drug/lipid interactions is a necessary and important step to fully clarify the role and action mechanism of active ingredients, as well as to shed light on possible complications caused by drug overdosage. In this paper, the influence of Benzocaine and Propranolol drugs on the structure of L-α-phosphatidylcholines-based membranes has been investigated by means of neutron reflectivity, grazing incidence small angle neutron scattering, and small/ultrasmall angle neutron scattering. Investigations allowed discovering a stiffening of the membranes as well as the formation of stalks, caused by the presence of Benzocaine. On the other hand, disordered bilayers (lamellar powders) and highly curved structures were found in the presence of Propranolol. The found results may be rationalized in terms of the molecular structure of drugs and may serve as starting point for explaining the toxic behavior in long-term and overdosage scenarios.
LB  - PUB:(DE-HGF)16
C6  - pmid:29181470
UR  - <Go to ISI:>//WOS:000417295800055
DO  - DOI:10.1039/C7CP06077G
UR  - https://juser.fz-juelich.de/record/838843
ER  -