Journal Article

FZJ-2017-07353

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Effect of Benzocaine and Propranolol on phospholipid-based bilayers

Mangiapia, G. (Corresponding author)FZJ* ; Gvaramia, M.FZJ* ; Kuhrts, L. ; Teixeira, J. ; Soltwedel, O. ; Frielinghaus, H.FZJ* ; Koutsioumpas, A.FZJ*

2017
RSC Publ. Cambridge

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Please use a persistent id in citations: http://hdl.handle.net/2128/16407  doi:10.1039/C7CP06077G

Abstract: Cell membranes play a fundamental role in protecting the cell from its surroundings, in addition to host many proteins with fundamental biological tasks. A study of drug/lipid interactions is a necessary and important step to fully clarify the role and action mechanism of active ingredients, as well as to shed light on possible complications caused by drug overdosage. In this paper, the influence of Benzocaine and Propranolol drugs on the structure of L-α-phosphatidylcholines-based membranes has been investigated by means of neutron reflectivity, grazing incidence small angle neutron scattering, and small/ultrasmall angle neutron scattering. Investigations allowed discovering a stiffening of the membranes as well as the formation of stalks, caused by the presence of Benzocaine. On the other hand, disordered bilayers (lamellar powders) and highly curved structures were found in the presence of Propranolol. The found results may be rationalized in terms of the molecular structure of drugs and may serve as starting point for explaining the toxic behavior in long-term and overdosage scenarios.

Keyword(s): Polymers, Soft Nano Particles and Proteins (1st) ; Soft Condensed Matter (2nd)

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Contributing Institute(s):

1. JCNS-FRM-II (JCNS (München) ; Jülich Centre for Neutron Science JCNS (München) ; JCNS-FRM-II)
2. Neutronenstreuung (Neutronenstreuung ; JCNS-1)

Research Program(s):

1. 6215 - Soft Matter, Health and Life Sciences (POF3-621) (POF3-621)
2. 6G15 - FRM II / MLZ (POF3-6G15) (POF3-6G15)
3. 6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623) (POF3-623)

Experiment(s):

1. MARIA: Magnetic reflectometer with high incident angle (NL5N)
2. NREX: Neutron reflectometer with X-ray option (NL1)
3. TREFF: Neutronenreflektometer (NL5S)
4. KWS-1: Small angle scattering diffractometer (NL3b)
5. KWS-3: Very small angle scattering diffractometer with focusing mirror (NL3auS)

Appears in the scientific report 2017

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Database coverage:
; ; Allianz-Lizenz / DFG ; Current Contents - Physical, Chemical and Earth Sciences ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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