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@ARTICLE{Mangiapia:838843,
      author       = {Mangiapia, Gaetano and Gvaramia, Manuchar and Kuhrts, Lucas
                      and Teixeira, Jose and Soltwedel, Olaf and Frielinghaus,
                      Henrich and Koutsioumpas, Alexandros},
      title        = {{E}ffect of {B}enzocaine and {P}ropranolol on
                      phospholipid-based bilayers},
      journal      = {Physical chemistry, chemical physics},
      volume       = {19},
      number       = {47},
      issn         = {1463-9084},
      address      = {Cambridge},
      publisher    = {RSC Publ.},
      reportid     = {FZJ-2017-07353},
      pages        = {32057-32071},
      year         = {2017},
      abstract     = {Cell membranes play a fundamental role in protecting the
                      cell from its surroundings, in addition to host many
                      proteins with fundamental biological tasks. A study of
                      drug/lipid interactions is a necessary and important step to
                      fully clarify the role and action mechanism of active
                      ingredients, as well as to shed light on possible
                      complications caused by drug overdosage. In this paper, the
                      influence of Benzocaine and Propranolol drugs on the
                      structure of L-α-phosphatidylcholines-based membranes has
                      been investigated by means of neutron reflectivity, grazing
                      incidence small angle neutron scattering, and
                      small/ultrasmall angle neutron scattering. Investigations
                      allowed discovering a stiffening of the membranes as well as
                      the formation of stalks, caused by the presence of
                      Benzocaine. On the other hand, disordered bilayers (lamellar
                      powders) and highly curved structures were found in the
                      presence of Propranolol. The found results may be
                      rationalized in terms of the molecular structure of drugs
                      and may serve as starting point for explaining the toxic
                      behavior in long-term and overdosage scenarios.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6215 - Soft Matter, Health and Life Sciences (POF3-621) /
                      6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6215 / G:(DE-HGF)POF3-6G15 /
                      G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)MARIA-20140101 / EXP:(DE-MLZ)N-REX-20140101 /
                      EXP:(DE-MLZ)TREFF-20140101 / EXP:(DE-MLZ)KWS1-20140101 /
                      EXP:(DE-MLZ)KWS3-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29181470},
      UT           = {WOS:000417295800055},
      doi          = {10.1039/C7CP06077G},
      url          = {https://juser.fz-juelich.de/record/838843},
}