TY  - JOUR
AU  - Hutterer, Markus
AU  - Bumes, Elisabeth
AU  - Riemenschneider, Markus J.
AU  - Grosse, Jirka
AU  - Hellwig, Dirk
AU  - Galldiks, Norbert
AU  - Langen, Karl-Josef
AU  - Hau, Peter
TI  - AIDS-Related Central Nervous System Toxoplasmosis With Increased 18F-Fluoroethyl-L-Tyrosine Amino Acid PET Uptake Due to LAT1/2 Expression of Inflammatory Cells
JO  - Clinical nuclear medicine
VL  - 42
IS  - 12
SN  - 0363-9762
CY  - Philadelphia, Pa.
PB  - Lippincott Williams & Wilkins
M1  - FZJ-2017-07360
SP  - e506 - e508
PY  - 2017
AB  - We report the case of a 40-year-old woman with a progressive right-sided hemiparesis. Standard MRI revealed a contrast-enhancing brain lesion within the left basal ganglia. 18Ffluoroethyl-L-tyrosine (18F-FET) PET showed a distinct tracer uptake (lesion-to-brain ratio [LBR]: LBRmax = 2.03, LBRmean = 1.68) with a significant larger metabolic lesion volume than contrast-enhancement in MRI, indicating cerebral glioma. Surprisingly, histopathologic analysis demonstrated central nervous system toxoplasmosis with pronounced inflammatory reaction (reactive astrogliosis, microglia activation, macrophage, and T-lymphocyte infiltration), which was associated with strong LAT1/LAT2/CD98 expression. In conclusion, inflammatory brain lesions, such as cerebral toxoplasmosis, represent a potential pitfall of 18F-FET PET mimicking a brain tumor.
LB  - PUB:(DE-HGF)16
C6  - pmid:29076908
UR  - <Go to ISI:>//WOS:000415755700005
DO  - DOI:10.1097/RLU.0000000000001873
UR  - https://juser.fz-juelich.de/record/838850
ER  -