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000840009 1001_ $$0P:(DE-HGF)0$$aBlenau, Wolfgang$$b0
000840009 245__ $$aPeaTAR1B: Characterization of a Second Type 1 Tyramine Receptor of the American Cockroach, Periplaneta americana
000840009 260__ $$aBasel$$bMolecular Diversity Preservation International$$c2017
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000840009 520__ $$aThe catecholamines norepinephrine and epinephrine regulate important physiological functions in vertebrates. In insects; these neuroactive substances are functionally replaced by the phenolamines octopamine and tyramine. Phenolamines activate specific guanine nucleotide-binding (G) protein-coupled receptors (GPCRs). Type 1 tyramine receptors are better activated by tyramine than by octopamine. In contrast; type 2 tyramine receptors are almost exclusively activated by tyramine. Functionally; activation of type 1 tyramine receptors leads to a decrease in the intracellular concentration of cAMP ([cAMP]i) whereas type 2 tyramine receptors can mediate Ca2+ signals or both Ca2+ signals and effects on [cAMP]i. Here; we report that the American cockroach (Periplaneta americana) expresses a second type 1 tyramine receptor (PeaTAR1B) in addition to PeaTAR1A (previously called PeaTYR1). When heterologously expressed in flpTM cells; activation of PeaTAR1B by tyramine leads to a concentration-dependent decrease in [cAMP]i. Its activity can be blocked by a series of established antagonists. The functional characterization of two type 1 tyramine receptors from P. americana; PeaTAR1A and PeaTAR1B; which respond to tyramine by changing cAMP levels; is a major step towards understanding the actions of tyramine in cockroach physiology and behavior; particularly in comparison to the effects of octopamine.
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000840009 7001_ $$0P:(DE-Juel1)131909$$aBalfanz, Sabine$$b1$$ufzj
000840009 7001_ $$0P:(DE-Juel1)131911$$aBaumann, A.$$b2$$eCorresponding author$$ufzj
000840009 773__ $$0PERI:(DE-600)2019364-6$$a10.3390/ijms18112279$$gVol. 18, no. 11, p. 2279 -$$n11$$p2279 -$$tInternational journal of molecular sciences$$v18$$x1422-0067$$y2017
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