% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Blenau:840009,
      author       = {Blenau, Wolfgang and Balfanz, Sabine and Baumann, A.},
      title        = {{P}ea{TAR}1{B}: {C}haracterization of a {S}econd {T}ype 1
                      {T}yramine {R}eceptor of the {A}merican {C}ockroach,
                      {P}eriplaneta americana},
      journal      = {International journal of molecular sciences},
      volume       = {18},
      number       = {11},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {FZJ-2017-07579},
      pages        = {2279 -},
      year         = {2017},
      abstract     = {The catecholamines norepinephrine and epinephrine regulate
                      important physiological functions in vertebrates. In
                      insects; these neuroactive substances are functionally
                      replaced by the phenolamines octopamine and tyramine.
                      Phenolamines activate specific guanine nucleotide-binding
                      (G) protein-coupled receptors (GPCRs). Type 1 tyramine
                      receptors are better activated by tyramine than by
                      octopamine. In contrast; type 2 tyramine receptors are
                      almost exclusively activated by tyramine. Functionally;
                      activation of type 1 tyramine receptors leads to a decrease
                      in the intracellular concentration of cAMP ([cAMP]i) whereas
                      type 2 tyramine receptors can mediate Ca2+ signals or both
                      Ca2+ signals and effects on [cAMP]i. Here; we report that
                      the American cockroach (Periplaneta americana) expresses a
                      second type 1 tyramine receptor (PeaTAR1B) in addition to
                      PeaTAR1A (previously called PeaTYR1). When heterologously
                      expressed in flpTM cells; activation of PeaTAR1B by tyramine
                      leads to a concentration-dependent decrease in [cAMP]i. Its
                      activity can be blocked by a series of established
                      antagonists. The functional characterization of two type 1
                      tyramine receptors from P. americana; PeaTAR1A and PeaTAR1B;
                      which respond to tyramine by changing cAMP levels; is a
                      major step towards understanding the actions of tyramine in
                      cockroach physiology and behavior; particularly in
                      comparison to the effects of octopamine.},
      cin          = {ICS-4},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-4-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000416811300053},
      pubmed       = {pmid:29084141},
      doi          = {10.3390/ijms18112279},
      url          = {https://juser.fz-juelich.de/record/840009},
}