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@ARTICLE{Minkova:840194,
      author       = {Minkova, Lora and Habich, Annegret and Peter, Jessica and
                      Kaller, Christoph P. and Eickhoff, Simon and Klöppel,
                      Stefan},
      title        = {{G}ray matter asymmetries in aging and neurodegeneration:
                      {A} review and meta-analysis},
      journal      = {Human brain mapping},
      volume       = {38},
      number       = {12},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2017-07748},
      pages        = {5890 - 5904},
      year         = {2017},
      abstract     = {Inter-hemispheric asymmetries are a common phenomenon of
                      the human brain. Some evidence suggests that
                      neurodegeneration related to aging and disease may
                      preferentially affect the left-usually language- and
                      motor-dominant-hemisphere. Here, we used activation
                      likelihood estimation meta-analysis to assess gray matter
                      (GM) loss and its lateralization in healthy aging and in
                      neurodegeneration, namely, mild cognitive impairment (MCI),
                      Alzheimer's dementia (AD), Parkinson's disease (PD), and
                      Huntington's disease (HD). This meta-analysis, comprising
                      159 voxel-based morphometry publications (enrolling 4,469
                      patients and 4,307 controls), revealed that GM decline
                      appeared to be asymmetric at trend levels but provided no
                      evidence for increased left-hemisphere vulnerability.
                      Regions with asymmetric GM decline were located in areas
                      primarily affected by neurodegeneration. In HD, the left
                      putamen showed converging evidence for more pronounced
                      atrophy, while no consistent pattern was found in PD. In
                      MCI, the right hippocampus was more atrophic than its left
                      counterpart, a pattern that reversed in AD. The stability of
                      these findings was confirmed using permutation tests.
                      However, due to the lenient threshold used in the asymmetry
                      analysis, further work is needed to confirm our results and
                      to provide a better understanding of the functional role of
                      GM asymmetries, for instance in the context of cognitive
                      reserve and compensation},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28856766},
      UT           = {WOS:000414683400005},
      doi          = {10.1002/hbm.23772},
      url          = {https://juser.fz-juelich.de/record/840194},
}