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000841557 1001_ $$0P:(DE-HGF)0$$aUmeokoli, Blessing O.$$b0
000841557 245__ $$aNew amide and dioxopiperazine derivatives from leaves of Breynia nivosa
000841557 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2017
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000841557 520__ $$aThe first chemical investigation of leaves of Breynia nivosa from Nigeria resulted in the isolation of two new amide derivatives breynivosamides A and B (1 and 2) and two new dioxopiperazine derivatives breynivosines A and B (4 and 5) together with seven known compounds (3, 6–11). The structures of the new compounds were elucidated by 1D, 2D NMR and HRESIMS data as well as by comparison with the literature. All isolated compounds were tested for the cytotoxic and antimicrobial activities. Only cristatin A (6) showed cytotoxicity against the L5178Y mouse lymphoma cell line with an IC50 value of 13.9 μM while breynivosamide A (1) exhibited moderate antimicrobial activity against Mycobacterium tuberculosis with an MIC value of 25 μM.
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000841557 7001_ $$0P:(DE-HGF)0$$aOnyegbule, Felix A.$$b1
000841557 7001_ $$0P:(DE-HGF)0$$aOkoye, Festus B. C.$$b2
000841557 7001_ $$0P:(DE-HGF)0$$aWang, Hao$$b3
000841557 7001_ $$0P:(DE-HGF)0$$aKalscheuer, Rainer$$b4
000841557 7001_ $$0P:(DE-HGF)0$$aMüller, Werner E. G.$$b5
000841557 7001_ $$0P:(DE-Juel1)132001$$aHartmann, Rudolf$$b6$$ufzj
000841557 7001_ $$0P:(DE-HGF)0$$aLiu, Zhen$$b7$$eCorresponding author
000841557 7001_ $$0P:(DE-HGF)0$$aProksch, Peter$$b8$$eCorresponding author
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