Journal Article

FZJ-2017-08595

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png New amide and dioxopiperazine derivatives from leaves of Breynia nivosa

Umeokoli, B. O. ; Onyegbule, F. A. ; Okoye, F. B. C. ; Wang, H. ; Kalscheuer, R. ; Müller, W. E. G. ; Hartmann, R.FZJ* ; Liu, Z. (Corresponding author) ; Proksch, P. (Corresponding author)

2017
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.fitote.2017.08.009

Abstract: The first chemical investigation of leaves of Breynia nivosa from Nigeria resulted in the isolation of two new amide derivatives breynivosamides A and B (1 and 2) and two new dioxopiperazine derivatives breynivosines A and B (4 and 5) together with seven known compounds (3, 6–11). The structures of the new compounds were elucidated by 1D, 2D NMR and HRESIMS data as well as by comparison with the literature. All isolated compounds were tested for the cytotoxic and antimicrobial activities. Only cristatin A (6) showed cytotoxicity against the L5178Y mouse lymphoma cell line with an IC50 value of 13.9 μM while breynivosamide A (1) exhibited moderate antimicrobial activity against Mycobacterium tuberculosis with an MIC value of 25 μM.

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Contributing Institute(s):

1. Strukturbiochemie (ICS-6)

Research Program(s):

1. 551 - Functional Macromolecules and Complexes (POF3-551) (POF3-551)

Appears in the scientific report 2018

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Database coverage:
; BIOSIS Previews ; Ebsco Academic Search ; IF < 5 ; NCBI Molecular Biology Database ; SCOPUS ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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