TY  - JOUR
AU  - Umeokoli, Blessing O.
AU  - Onyegbule, Felix A.
AU  - Okoye, Festus B. C.
AU  - Wang, Hao
AU  - Kalscheuer, Rainer
AU  - Müller, Werner E. G.
AU  - Hartmann, Rudolf
AU  - Liu, Zhen
AU  - Proksch, Peter
TI  - New amide and dioxopiperazine derivatives from leaves of Breynia nivosa
JO  - Fitoterapia
VL  - 122
SN  - 0367-326X
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2017-08595
SP  - 16-19
PY  - 2017
AB  - The first chemical investigation of leaves of Breynia nivosa from Nigeria resulted in the isolation of two new amide derivatives breynivosamides A and B (1 and 2) and two new dioxopiperazine derivatives breynivosines A and B (4 and 5) together with seven known compounds (3, 6–11). The structures of the new compounds were elucidated by 1D, 2D NMR and HRESIMS data as well as by comparison with the literature. All isolated compounds were tested for the cytotoxic and antimicrobial activities. Only cristatin A (6) showed cytotoxicity against the L5178Y mouse lymphoma cell line with an IC50 value of 13.9 μM while breynivosamide A (1) exhibited moderate antimicrobial activity against Mycobacterium tuberculosis with an MIC value of 25 μM.
LB  - PUB:(DE-HGF)16
C6  - pmid:28830789
UR  - <Go to ISI:>//WOS:000413383500004
DO  - DOI:10.1016/j.fitote.2017.08.009
UR  - https://juser.fz-juelich.de/record/841557
ER  -