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@ARTICLE{Umeokoli:841557,
      author       = {Umeokoli, Blessing O. and Onyegbule, Felix A. and Okoye,
                      Festus B. C. and Wang, Hao and Kalscheuer, Rainer and
                      Müller, Werner E. G. and Hartmann, Rudolf and Liu, Zhen and
                      Proksch, Peter},
      title        = {{N}ew amide and dioxopiperazine derivatives from leaves of
                      {B}reynia nivosa},
      journal      = {Fitoterapia},
      volume       = {122},
      issn         = {0367-326X},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2017-08595},
      pages        = {16-19},
      year         = {2017},
      abstract     = {The first chemical investigation of leaves of Breynia
                      nivosa from Nigeria resulted in the isolation of two new
                      amide derivatives breynivosamides A and B (1 and 2) and two
                      new dioxopiperazine derivatives breynivosines A and B (4 and
                      5) together with seven known compounds (3, 6–11). The
                      structures of the new compounds were elucidated by 1D, 2D
                      NMR and HRESIMS data as well as by comparison with the
                      literature. All isolated compounds were tested for the
                      cytotoxic and antimicrobial activities. Only cristatin A (6)
                      showed cytotoxicity against the L5178Y mouse lymphoma cell
                      line with an IC50 value of 13.9 μM while breynivosamide A
                      (1) exhibited moderate antimicrobial activity against
                      Mycobacterium tuberculosis with an MIC value of 25 μM.},
      cin          = {ICS-6},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28830789},
      UT           = {WOS:000413383500004},
      doi          = {10.1016/j.fitote.2017.08.009},
      url          = {https://juser.fz-juelich.de/record/841557},
}