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000841558 1001_ $$0P:(DE-HGF)0$$aMokhlesi, Amin$$b0
000841558 245__ $$aNew 2-Methoxy Acetylenic Acids and Pyrazole Alkaloids from the Marine Sponge Cinachyrella sp.
000841558 260__ $$aBasel$$c2017
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000841558 520__ $$aThree new 2-methoxy acetylenic acids (1–3) and a known derivative (4), in addition to three new natural pyrazole alkaloids (5–7) were isolated from an Indonesian marine sponge of the genus Cinachyrella. Compounds 5 and 6 have previously been reported as synthetic compounds. The structures of the new compounds were established on the basis of one- and two-dimensional NMR spectroscopy as well as by mass spectrometric data. The absolute configuration of the new acetylenic acid derivatives (1–3) was established by ECD spectroscopy. All isolated compounds were evaluated for their cytotoxicity against L5178Y mouse lymphoma cells. Compounds 1–4 exhibited strong activity with an IC50 value of 0.3 µM. A plausible biosynthetic pathway for the pyrazole metabolites 5–7 is proposed.
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000841558 7001_ $$0P:(DE-Juel1)132001$$aHartmann, Rudolf$$b1$$ufzj
000841558 7001_ $$0P:(DE-HGF)0$$aKurtán, Tibor$$b2
000841558 7001_ $$0P:(DE-HGF)0$$aWeber, Horst$$b3
000841558 7001_ $$0P:(DE-HGF)0$$aLin, Wenhan$$b4
000841558 7001_ $$0P:(DE-HGF)0$$aChaidir, Chaidir$$b5
000841558 7001_ $$0P:(DE-HGF)0$$aMüller, Werner E. G.$$b6
000841558 7001_ $$0P:(DE-HGF)0$$aDaletos, Georgios$$b7$$eCorresponding author
000841558 7001_ $$0P:(DE-HGF)0$$aProksch, Peter$$b8$$eCorresponding author
000841558 773__ $$0PERI:(DE-600)2175190-0$$a10.3390/md15110356$$p356$$tMarine drugs$$v15$$x1660-3397$$y2017
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