Journal Article

FZJ-2017-08596

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png New 2-Methoxy Acetylenic Acids and Pyrazole Alkaloids from the Marine Sponge Cinachyrella sp.

Mokhlesi, A. ; Hartmann, R.FZJ* ; Kurtán, T. ; Weber, H. ; Lin, W. ; Chaidir, C. ; Müller, W. E. G. ; Daletos, G. (Corresponding author) ; Proksch, P. (Corresponding author)

2017
Basel

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Please use a persistent id in citations: http://hdl.handle.net/2128/17602  doi:10.3390/md15110356

Abstract: Three new 2-methoxy acetylenic acids (1–3) and a known derivative (4), in addition to three new natural pyrazole alkaloids (5–7) were isolated from an Indonesian marine sponge of the genus Cinachyrella. Compounds 5 and 6 have previously been reported as synthetic compounds. The structures of the new compounds were established on the basis of one- and two-dimensional NMR spectroscopy as well as by mass spectrometric data. The absolute configuration of the new acetylenic acid derivatives (1–3) was established by ECD spectroscopy. All isolated compounds were evaluated for their cytotoxicity against L5178Y mouse lymphoma cells. Compounds 1–4 exhibited strong activity with an IC50 value of 0.3 µM. A plausible biosynthetic pathway for the pyrazole metabolites 5–7 is proposed.

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Contributing Institute(s):

1. Strukturbiochemie (ICS-6)

Research Program(s):

1. 551 - Functional Macromolecules and Complexes (POF3-551) (POF3-551)

Appears in the scientific report 2018

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Database coverage:
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