TY  - JOUR
AU  - Mokhlesi, Amin
AU  - Hartmann, Rudolf
AU  - Kurtán, Tibor
AU  - Weber, Horst
AU  - Lin, Wenhan
AU  - Chaidir, Chaidir
AU  - Müller, Werner E. G.
AU  - Daletos, Georgios
AU  - Proksch, Peter
TI  - New 2-Methoxy Acetylenic Acids and Pyrazole Alkaloids from the Marine Sponge Cinachyrella sp.
JO  - Marine drugs
VL  - 15
SN  - 1660-3397
CY  - Basel
M1  - FZJ-2017-08596
SP  - 356
PY  - 2017
AB  - Three new 2-methoxy acetylenic acids (1–3) and a known derivative (4), in addition to three new natural pyrazole alkaloids (5–7) were isolated from an Indonesian marine sponge of the genus Cinachyrella. Compounds 5 and 6 have previously been reported as synthetic compounds. The structures of the new compounds were established on the basis of one- and two-dimensional NMR spectroscopy as well as by mass spectrometric data. The absolute configuration of the new acetylenic acid derivatives (1–3) was established by ECD spectroscopy. All isolated compounds were evaluated for their cytotoxicity against L5178Y mouse lymphoma cells. Compounds 1–4 exhibited strong activity with an IC50 value of 0.3 µM. A plausible biosynthetic pathway for the pyrazole metabolites 5–7 is proposed.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000416600200026
C6  - pmid:29137125
DO  - DOI:10.3390/md15110356
UR  - https://juser.fz-juelich.de/record/841558
ER  -