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@ARTICLE{Mokhlesi:841558,
      author       = {Mokhlesi, Amin and Hartmann, Rudolf and Kurtán, Tibor and
                      Weber, Horst and Lin, Wenhan and Chaidir, Chaidir and
                      Müller, Werner E. G. and Daletos, Georgios and Proksch,
                      Peter},
      title        = {{N}ew 2-{M}ethoxy {A}cetylenic {A}cids and {P}yrazole
                      {A}lkaloids from the {M}arine {S}ponge {C}inachyrella sp.},
      journal      = {Marine drugs},
      volume       = {15},
      issn         = {1660-3397},
      address      = {Basel},
      reportid     = {FZJ-2017-08596},
      pages        = {356},
      year         = {2017},
      abstract     = {Three new 2-methoxy acetylenic acids (1–3) and a known
                      derivative (4), in addition to three new natural pyrazole
                      alkaloids (5–7) were isolated from an Indonesian marine
                      sponge of the genus Cinachyrella. Compounds 5 and 6 have
                      previously been reported as synthetic compounds. The
                      structures of the new compounds were established on the
                      basis of one- and two-dimensional NMR spectroscopy as well
                      as by mass spectrometric data. The absolute configuration of
                      the new acetylenic acid derivatives (1–3) was established
                      by ECD spectroscopy. All isolated compounds were evaluated
                      for their cytotoxicity against L5178Y mouse lymphoma cells.
                      Compounds 1–4 exhibited strong activity with an IC50 value
                      of 0.3 µM. A plausible biosynthetic pathway for the
                      pyrazole metabolites 5–7 is proposed.},
      cin          = {ICS-6},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000416600200026},
      pubmed       = {pmid:29137125},
      doi          = {10.3390/md15110356},
      url          = {https://juser.fz-juelich.de/record/841558},
}