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000841562 0247_ $$2doi$$a10.3390/md15110359
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000841562 1001_ $$0P:(DE-HGF)0$$aKüppers, Lisa$$b0
000841562 245__ $$aLactones from the Sponge-Derived Fungus Talaromyces rugulosus
000841562 260__ $$aBasel$$c2017
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000841562 520__ $$aThe marine-derived fungus Talaromyces rugulosus isolated from the Mediterranean sponge Axinella cannabina and cultured on solid rice medium yielded seventeen lactone derivatives including five butenolides (1–5), seven (3S)-resorcylide derivatives (6–12), two butenolide-resorcylide dimers (13 and 14), and three dihydroisocoumarins (15–17). Among them, fourteen compounds (1–3, 6–16) are new natural products. The structures of the isolated compounds were elucidated by 1D and 2D NMR (Nuclear Magnetic Resonance) spectroscopy as well as by ESI-HRMS (ElectroSpray Ionization-High Resolution Mass Spectrometry). TDDFT-ECD (Time-Dependent Density Functional Theory-Electronic Circular Dichroism) calculations were performed to determine the absolute configurations of chiral compounds. The butenolide-resorcylide dimers talarodilactones A and B (13 and 14) exhibited potent cytotoxicity against the L5178Y murine lymphoma cell line with IC50 values of 3.9 and 1.3 µM, respectively.
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000841562 7001_ $$0P:(DE-HGF)0$$aEbrahim, Weaam$$b1
000841562 7001_ $$0P:(DE-HGF)0$$aEl-Neketi, Mona$$b2
000841562 7001_ $$0P:(DE-HGF)0$$aÖzkaya, Ferhat C.$$b3
000841562 7001_ $$0P:(DE-HGF)0$$aMándi, Attila$$b4
000841562 7001_ $$0P:(DE-HGF)0$$aKurtán, Tibor$$b5
000841562 7001_ $$0P:(DE-HGF)0$$aOrfali, Raha S.$$b6
000841562 7001_ $$0P:(DE-HGF)0$$aMüller, Werner E. G.$$b7
000841562 7001_ $$0P:(DE-Juel1)132001$$aHartmann, Rudolf$$b8$$ufzj
000841562 7001_ $$0P:(DE-HGF)0$$aLin, Wenhan$$b9
000841562 7001_ $$0P:(DE-HGF)0$$aSong, Weiguo$$b10
000841562 7001_ $$0P:(DE-HGF)0$$aLiu, Zhen$$b11$$eCorresponding author
000841562 7001_ $$0P:(DE-HGF)0$$aProksch, Peter$$b12$$eCorresponding author
000841562 773__ $$0PERI:(DE-600)2175190-0$$a10.3390/md15110359$$p359$$tMarine drugs$$v15$$x1660-3397$$y2017
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