Journal Article

FZJ-2017-08600

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Lactones from the Sponge-Derived Fungus Talaromyces rugulosus

Küppers, L. ; Ebrahim, W. ; El-Neketi, M. ; Özkaya, F. C. ; Mándi, A. ; Kurtán, T. ; Orfali, R. S. ; Müller, W. E. G. ; Hartmann, R.FZJ* ; Lin, W. ; Song, W. ; Liu, Z. (Corresponding author) ; Proksch, P. (Corresponding author)

2017
Basel

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Please use a persistent id in citations: http://hdl.handle.net/2128/17609  doi:10.3390/md15110359

Abstract: The marine-derived fungus Talaromyces rugulosus isolated from the Mediterranean sponge Axinella cannabina and cultured on solid rice medium yielded seventeen lactone derivatives including five butenolides (1–5), seven (3S)-resorcylide derivatives (6–12), two butenolide-resorcylide dimers (13 and 14), and three dihydroisocoumarins (15–17). Among them, fourteen compounds (1–3, 6–16) are new natural products. The structures of the isolated compounds were elucidated by 1D and 2D NMR (Nuclear Magnetic Resonance) spectroscopy as well as by ESI-HRMS (ElectroSpray Ionization-High Resolution Mass Spectrometry). TDDFT-ECD (Time-Dependent Density Functional Theory-Electronic Circular Dichroism) calculations were performed to determine the absolute configurations of chiral compounds. The butenolide-resorcylide dimers talarodilactones A and B (13 and 14) exhibited potent cytotoxicity against the L5178Y murine lymphoma cell line with IC50 values of 3.9 and 1.3 µM, respectively.

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Contributing Institute(s):

1. Strukturbiochemie (ICS-6)

Research Program(s):

1. 551 - Functional Macromolecules and Complexes (POF3-551) (POF3-551)

Appears in the scientific report 2018

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Database coverage:
; ; ; ; BIOSIS Previews ; DOAJ Seal ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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