TY  - JOUR
AU  - Küppers, Lisa
AU  - Ebrahim, Weaam
AU  - El-Neketi, Mona
AU  - Özkaya, Ferhat C.
AU  - Mándi, Attila
AU  - Kurtán, Tibor
AU  - Orfali, Raha S.
AU  - Müller, Werner E. G.
AU  - Hartmann, Rudolf
AU  - Lin, Wenhan
AU  - Song, Weiguo
AU  - Liu, Zhen
AU  - Proksch, Peter
TI  - Lactones from the Sponge-Derived Fungus Talaromyces rugulosus
JO  - Marine drugs
VL  - 15
SN  - 1660-3397
CY  - Basel
M1  - FZJ-2017-08600
SP  - 359
PY  - 2017
AB  - The marine-derived fungus Talaromyces rugulosus isolated from the Mediterranean sponge Axinella cannabina and cultured on solid rice medium yielded seventeen lactone derivatives including five butenolides (1–5), seven (3S)-resorcylide derivatives (6–12), two butenolide-resorcylide dimers (13 and 14), and three dihydroisocoumarins (15–17). Among them, fourteen compounds (1–3, 6–16) are new natural products. The structures of the isolated compounds were elucidated by 1D and 2D NMR (Nuclear Magnetic Resonance) spectroscopy as well as by ESI-HRMS (ElectroSpray Ionization-High Resolution Mass Spectrometry). TDDFT-ECD (Time-Dependent Density Functional Theory-Electronic Circular Dichroism) calculations were performed to determine the absolute configurations of chiral compounds. The butenolide-resorcylide dimers talarodilactones A and B (13 and 14) exhibited potent cytotoxicity against the L5178Y murine lymphoma cell line with IC50 values of 3.9 and 1.3 µM, respectively.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000416600200029
C6  - pmid:29135916
DO  - DOI:10.3390/md15110359
UR  - https://juser.fz-juelich.de/record/841562
ER  -