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@ARTICLE{Kppers:841562,
      author       = {Küppers, Lisa and Ebrahim, Weaam and El-Neketi, Mona and
                      Özkaya, Ferhat C. and Mándi, Attila and Kurtán, Tibor and
                      Orfali, Raha S. and Müller, Werner E. G. and Hartmann,
                      Rudolf and Lin, Wenhan and Song, Weiguo and Liu, Zhen and
                      Proksch, Peter},
      title        = {{L}actones from the {S}ponge-{D}erived {F}ungus
                      {T}alaromyces rugulosus},
      journal      = {Marine drugs},
      volume       = {15},
      issn         = {1660-3397},
      address      = {Basel},
      reportid     = {FZJ-2017-08600},
      pages        = {359},
      year         = {2017},
      abstract     = {The marine-derived fungus Talaromyces rugulosus isolated
                      from the Mediterranean sponge Axinella cannabina and
                      cultured on solid rice medium yielded seventeen lactone
                      derivatives including five butenolides (1–5), seven
                      (3S)-resorcylide derivatives (6–12), two
                      butenolide-resorcylide dimers (13 and 14), and three
                      dihydroisocoumarins (15–17). Among them, fourteen
                      compounds (1–3, 6–16) are new natural products. The
                      structures of the isolated compounds were elucidated by 1D
                      and 2D NMR (Nuclear Magnetic Resonance) spectroscopy as well
                      as by ESI-HRMS (ElectroSpray Ionization-High Resolution Mass
                      Spectrometry). TDDFT-ECD (Time-Dependent Density Functional
                      Theory-Electronic Circular Dichroism) calculations were
                      performed to determine the absolute configurations of chiral
                      compounds. The butenolide-resorcylide dimers
                      talarodilactones A and B (13 and 14) exhibited potent
                      cytotoxicity against the L5178Y murine lymphoma cell line
                      with IC50 values of 3.9 and 1.3 µM, respectively.},
      cin          = {ICS-6},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000416600200029},
      pubmed       = {pmid:29135916},
      doi          = {10.3390/md15110359},
      url          = {https://juser.fz-juelich.de/record/841562},
}