%0 Journal Article
%A Königs, Uwe
%A Humpert, Swen
%A Spahn, Ingo
%A Qaim, Syed M.
%A Neumaier, Bernd
%T Isolation of high purity 73Se using solid phase extraction after selective 4,5-[73Se]benzopiazselenol formation with aminonaphthalene
%J Radiochimica acta
%V 106
%N 6
%@ 0033-8230
%C Berlin
%I De Gruyter
%M FZJ-2018-01383
%P 497–505
%D 2018
%X A fast and efficient process for the productionof the PET radionuclide 73Se was developed using 75Se as asurrogate. 75Se was separated from proton irradiated arsenictrioxide by reaction with 2,3-diaminonaphthalene to4,5-[75Se]benzopiazelenol. This compound was purifiedusing SPE column chromatography and subsequentlydecomposed with hydrogen peroxide. For further chemicalconversions [75Se]selenite was reduced to elemental[75Se]selenium by either using thiosulfate or sulfur dioxide.The recovery yield of 75Se from the target amountedto 43 %. The utility of the isolated 75Se for radiosyntheseswas demonstrated by the successful preparation of [75Se]selenomethionine.The methodology developed using 75Sewas successfully transformed to 73Se.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000433962300005
%R 10.1515/ract-2017-2864
%U https://juser.fz-juelich.de/record/843844