Journal Article

FZJ-2018-01383

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Isolation of high purity 73Se using solid phase extraction after selective 4,5-[73Se]benzopiazselenol formation with aminonaphthalene

Königs, U.FZJ* ; Humpert, S.FZJ* ; Spahn, I.FZJ* ; Qaim, S. M.FZJ* ; Neumaier, B. (Corresponding author)FZJ*

2018
De Gruyter Berlin

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Please use a persistent id in citations: http://hdl.handle.net/2128/20717  doi:10.1515/ract-2017-2864

Abstract: A fast and efficient process for the productionof the PET radionuclide 73Se was developed using 75Se as asurrogate. 75Se was separated from proton irradiated arsenictrioxide by reaction with 2,3-diaminonaphthalene to4,5-[75Se]benzopiazelenol. This compound was purifiedusing SPE column chromatography and subsequentlydecomposed with hydrogen peroxide. For further chemicalconversions [75Se]selenite was reduced to elemental[75Se]selenium by either using thiosulfate or sulfur dioxide.The recovery yield of 75Se from the target amountedto 43 %. The utility of the isolated 75Se for radiosyntheseswas demonstrated by the successful preparation of [75Se]selenomethionine.The methodology developed using 75Sewas successfully transformed to 73Se.

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Contributing Institute(s):

1. Nuklearchemie (INM-5)

Research Program(s):

1. 573 - Neuroimaging (POF3-573) (POF3-573)

Appears in the scientific report 2018

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Database coverage:
; ; Current Contents - Physical, Chemical and Earth Sciences ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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