TY  - JOUR
AU  - Königs, Uwe
AU  - Humpert, Swen
AU  - Spahn, Ingo
AU  - Qaim, Syed M.
AU  - Neumaier, Bernd
TI  - Isolation of high purity 73Se using solid phase extraction after selective 4,5-[73Se]benzopiazselenol formation with aminonaphthalene
JO  - Radiochimica acta
VL  - 106
IS  - 6
SN  - 0033-8230
CY  - Berlin
PB  - De Gruyter
M1  - FZJ-2018-01383
SP  - 497–505
PY  - 2018
AB  - A fast and efficient process for the productionof the PET radionuclide 73Se was developed using 75Se as asurrogate. 75Se was separated from proton irradiated arsenictrioxide by reaction with 2,3-diaminonaphthalene to4,5-[75Se]benzopiazelenol. This compound was purifiedusing SPE column chromatography and subsequentlydecomposed with hydrogen peroxide. For further chemicalconversions [75Se]selenite was reduced to elemental[75Se]selenium by either using thiosulfate or sulfur dioxide.The recovery yield of 75Se from the target amountedto 43 %. The utility of the isolated 75Se for radiosyntheseswas demonstrated by the successful preparation of [75Se]selenomethionine.The methodology developed using 75Sewas successfully transformed to 73Se.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000433962300005
DO  - DOI:10.1515/ract-2017-2864
UR  - https://juser.fz-juelich.de/record/843844
ER  -